History and Objectives: Hodgkin's disease is a disorder of lymphoid tissues and is the most common malignancies among adults. Since infection is a causative factor, this study was carried out on two patients from a family in Shaheed Beheshti hospital in Kashan in 1999. The first patient was an 18-year man with chest pain, respiratory distress, weakness, weight loss and nightly perspiration and the second patient was his 12-yerar sister with weakness, weight loss and respiratory distress. The definite diagnosis of Hodgkin's disease was done according to biopsy.

Conclusion and Recommendations: There was much evidence for infection and genetic history as causative factors. Therefore, appropriate measures should be taken to avoid contacts between individuals and to prevent the development of the disorder.