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Feyz 2017, 21(1): 1-8 Back to browse issues page
Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide
Mojtaba Eizadi *, Ali Asghar Ravasi, Rahman Soori, Kazem Baesi, Sirus Choubineh
Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, I. R. Iran. , izadimojtaba2006@yahoo.com
Abstract:   (4556 Views)

Background: Although less is known about the molecular mechanisms responsible for its genetic compatibility, regular training is identified as a non-pharmacological treatment for obesity and type-II diabetes. This study aimed to determine the effect of a 3 months aerobic training on pancreatic TCF7L2 expression and glycemic profile in type II diabetic rats.

Materials and Methods: In this experimental study, type II diabetes was induced in male Wistar rats (n=16, weight: 220±30 g) by intraperitoneal injection of streptozotocin- nicotinamide. Animals were randomly divided into Exercise (n=8) and Control (n=8) groups. Exercise group, but not Control group, was completed a 3 month aerobic training (3 sessions/week). Forty-eight hours after the last exercise session, the relative expression of pancreatic TCF7L2, fasting glucose and serum insulin were measured in two groups.

Results: Compared to Control rats, exercise resulted in a significant decrease in fasting glucose in Exercise group (P=0.001). Serum insulin was increased significantly by aerobic training in Exercise group compared to Control one (P=0.014). However, pancreatic TCF7L2 expression   did not change by aerobic training (P=0.876).

Conclusion: Based on these data, while we concluded that a long-term aerobic training effectively improves the glycemic profile and insulin concentration of type II diabetic rats, such improvements cannot be attributed to TCF7L2 expression in pancreatic tissue.

Keywords: TCF7L2 Gene, Pancreas, Rat induced diabetes, Streptozotocin/nicotinamide, Aerobic training
Full-Text [PDF 256 kb]   (1989 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/02/25 | Revised: 2017/07/17 | Accepted: 2017/02/25 | Published: 2017/02/25
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Eizadi M, Ravasi A A, Soori R, Baesi K, Choubineh S. Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide. Feyz 2017; 21 (1) :1-8
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