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:: Volume 20, Issue 4 (Bimonthly 2016) ::
Feyz Med Sci J 2016, 20(4): 323-330 Back to browse issues page
Comparing buspirone effect with the extract of borage (Echium amoneum L) flower on learning in adult male rats
Zeynab Javid , Seyyed Ebrahim Hoseini *
Department of Psychology, Shiraz Branch, Islamic Azad University, Shiraz, I. R. Iran. , ebrahim.hossini@yahoo.com
Abstract:   (4832 Views)

Background: Learning as one of the higher functions of the brain is affected by several factors. Anxiety disorders are among the factors result in learning disorders. Considering the side-effects of anxiolytics, this study aimed to compare the effects of buspirone with borage flower extract on learning in adult male rats.

Materials and Methods: In this experimental study, adult male rats (no=40) were divided into 5 groups: Control, Sham and 3 Experimental groups (Buspirone 5 mg /kg, Borage extracts 150 mg/kg and Buspirone+extract). All injections were carried out intraperitoneally for 14 days. Conditioned Place Preference was used to assess the learning.

Results: The results of Extract group showed a significant improvement after 7 days of drug injection (P0.05). In addition, a significant improvement was observed in Buspirone, Extract and  Buspirone + Extract groups 14 days after drug injection.

Conclusion: The results of the study showed that the buspirone and the borage augment the   learning in rats.

Keywords: Buspirone, Borago officinalis, Learning, Rat
Full-Text [PDF 225 kb]   (17062 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/10 | Revised: 2017/08/1 | Accepted: 2016/10/10 | Published: 2016/10/10
References
1. Laroche S, Davis S, Jay TM. Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation. Hippocampus 2000; 10(4): 438-46.
2. Tavakoli F, Hoseini S, Mokhtari M, Vahdati A. Effect of memory attenuation and light music on morphine dependency in male mature mice using conditioned place preference. Feyz 2014; 18(1): 1-8. [in Persian]
3. Sarihi A, Mohammadi Z, Mirazi N, Komaki A. Effect of post-training flumazenil administration on baclofen-induced amnesia in passive avoidance learning. Feyz 2014; 18(2): 110-15. [in Persian]
4. Sylvers P, Lilienfeld SO, LaPrairie JL. Differences between trait fear and trait anxiety: Implications for psychopathology. Clin Psychol Rev 2011; 31(1): 122-37.
5. Sayyah M, Siahpoosh A, Khalili H, Malayeri A, Samaee H. A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder. Iran J Pharm Res 2012; 11(2): 697-01.
6. Heidari MR, Mandegary A, Hosseini A, Vahedian M. Anticonvulsant Effect of Methanolic Extract of Echium amoenum Fisch and C.A. Mey. Against Seizure Induced by Picrotoxin in Mice. Pakistan J Biological Sci 2006; 9(4): 772-76.
7. Ranjbar A, Khorami S, Safarabadi M, Shahmoradi A, Malekirad AA, Vakilian K, et al. Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross-sectional Before/After Clinical Trial. Evid Based Complement Alternat Med 2006; 3(4): 469-73.
8. Min J, Yu SW, Baek SH, Nair KM, Bae ON, Bhatt A, et al. Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. Neurosci Lett 2011; 500(3): 157-61.
9. Hwang MK, Kang NJ, Heo YS, Lee KW, Lee HJ. Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. Biochem Pharmacol 2009; 77(7): 1213-22.
10. Abolhassani M. Antibacterial effect of borage (Echium amoenum) on Staphylococcus aureus. Braz J Infect Dis 2004; 8(5): 382-5.
11. Heidari MR, Azad EM, Mehrabani M. Evaluation of the analgesic effect of Echium amoenum Fisch and C.A. Mey. extract in mice: Possible mechanism involved. J Ethnopharmacol 2006; 103(3): 345-9.
12. Rabbani M, Sajjadi SE, Vaseghi G, Jafarian A. Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice. Fitoterapia 2004; 75(5): 457-64.
13. Batool F. Buspirone and Anxiety Disorders: A Review with Pharmacological and Clinical Perspectives. Internet J Pharmacol 2007; 5(2): 1-6.
14. Amirghofran Z, Azadbakht M, Keshavarzi F. Echium amoenum stimulate of lymphocyte proliferation and inhibit of humoral antibody synthesis. Iran J Basic Med Sci 2000; 25(3-4): 119-24.
15. Sayyah M, Boostani H, Pakseresht S, Malaieri A. Efficacy of aqueous extract of Echium amoenum in treatment of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33(8): 1513-16.
16. Komaki A, Rasouli B , Shahidi S. Anxiolytic Effect of Borago officinalis (Boraginaceae) Extract in Male Rats. Avicenna J Neuro Psych Physiol 2015; 2(1): e27189.
17. Safaeian L, Azami Tameh A, Ghannadi A, Akbari Naghani E, Tavazoei H, Alavi SS. Protective effects of Echium amoenum Fisch. and C.A. Mey.against cerebral ischemia in the rats. Adv Biomed Res 2015; 4(1): 107-13.
18. Mrudula G, Vrushabendra swamy BM, Jayaveera KN. Evaluation of nootropic activity of leaves of Boragoofficinalis. Res J Pharm Biol Chem Sci 2012; 3(3): 405-14.
19. Zargooshnia S, Shahidi S, Ghahremani-tamadon F, Nikkhah A, Mehdizadeh M, Soleimani Asl S.The protective effect of Borago Officinalis extract on amyloid β (25–35)-induced long term potentiation disruption in the dentate gyrus of male rats. Metabolic Brain Dis 2015; 30(1): 151-6.
20. Holmes A, Parmigiani PF, Ferrari PF, Palanza P, Rodgers RJ. Behavioral profile of wild mice in the elevated plus-maze test for anxiety. Physiol Behav 2000; 71(5): 509-16.
21. Winsauer PJ, Delatte MS, Stevenson MW, Moerschbaecher JM. Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys. Exp Clin Psychopharmacol 2002; 10(4): 392-9.
22. Pache DM, Fernandez-Perez S, Sewell RD. Buspirone differentially modifies short-term memoryfunction in a combined delayed matching/non-matching to position task. Eur J Pharmacol 2003; 477(3): 205-11.
23. Bardo MT, Bevins RA. Conditioned place preference: what does it add to our preclinical understanding of drug reward?. Psychopharmacology (Berl) 2000; 153(1): 31-43.
24. Regard M, Knoch D, Gütling E, Landis T. Brain Damage and Addictive Behavior. A Neuropsychological and Electroencephalogram Investigation. Cog Behav Neurol 2003; 16(1): 47–53.
25. Asadollahpour A, Fata L, Gharraee B. Metacognitive Anxiety and Immediate and Delayed Judgment of Learning: Discovering the Underlying Mechanisms of Anxiety in Wells’ Theory. Iran J Psychiatry Clin Psychol 2011; 16(4): 412-19.
26. Funada M, Sato M, Makino Y, Wada K. Evaluation of rewarding effect of toluene by the conditioned place preference procedure in mice. Brain Res Brain Res Protoc 2002; 10(1): 47-54.
27. Safaeian L, Tameh AA, Ghannadi A, Akbari Naghani E, Tavazoei H, Alavi SS. Protective effects of Echium amoenum Fisch. and C.A. Mey. against cerebral ischemia in the rats. Adv Biomed Res 2015; 4(1): 107-12.
28. Christina M, Kory M, Sarah M, Chlebowski E, Shaw P, Cheng J, et al. A Combined Therapeutic Regimen of Buspirone and Environmental Enrichment Is More Efficacious than Either Alone in Enhancing Spatial Learning in Brain-Injured Pediatric Rats. J Neurotrauma 2014; 31(23): 1934-41.
29. Jay TM. Dopamine: A potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol 2003; 69(6): 375-90.
30. Zarrindast MR, Barghi-Lashkari S, Shafizadeh M. The possible cross-tolerance between morphine- and nicotineinduced hypothermia in mice. Pharmacol Biochemistry Behav 2001; 68(2): 283-89.
31. Lisman JE, Grace AA. The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 2005; 46(5): 703-13.
32. Kline AE, Massucci JL, Marion DW, Dixon CE. Attenution of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected of traumatic brain injury by controlled cortical impact. J Neurotroma 2002; 19(4): 415-25.
33. Floresco SB, Magyar O, Ghods-Sharifi S, Vexelman C, Tse MT. Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting. Neuropsychopharmacology 2006; 31(2): 297-09.
34. Liggins JT. The roles of Dopamine D1 and D2 receptors in working memory function. MSURJ 2009; 4(1): 39-44.
35. Faryadian S, Sydmohammadi A, Khosravi A, Kashiri M, Faryadayn P, Abasi N. Aqueous Extract of Echium amoenum Elevate CSF Serotonin and Dopamine Level in Depression rat. Biomedical Pharmacol J 2014; 7(1): 137-42.
36. Winsauer PJ, Delatte MS, Stevenson MW, Moerschbaecher JM. Effects of triazolam, 8-OH-DPAT, and buspirone on repeated acquisition in squirrel monkeys. Exp Clin Psychopharma 2002; 10(4) :392-9.
37. Ramirez MR, Izquierdo I, do Carmo BassolsRaseira M, Zuanazzi J, Barros D, Henriques A. Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats. Pharmacol Res 2005; 52(6): 457-62.
38. Nazarzadeh F, Moini F, Aghamohamadian H, Abdkhoda M. Autobiographical memory and metacognition in patients with obsessive-compulsive disorder and social anxiety. J Shahrekord Univ Med Sci 2015; 16 (6): 57-66. [in Persian]
39. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drug 2008; 68(13): 1803-39.
40. Javid Z, Hosseini SE. Comparison of the Effect of Echium amoenum with Buspironeon the Anxiety of Cruciate Maze in Adult Male Rats. Horizon Med Sci 2015; 21(4): 271-6. [in Persian]
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Javid Z, Hoseini S E. Comparing buspirone effect with the extract of borage (Echium amoneum L) flower on learning in adult male rats. Feyz Med Sci J 2016; 20 (4) :323-330
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Volume 20, Issue 4 (Bimonthly 2016) Back to browse issues page
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