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:: Volume 19, Issue 5 (Bimonthly 2015) ::
Feyz 2015, 19(5): 382-390 Back to browse issues page
The effect of a six-week swimming training program combined with Aloe vera extract on human epidermal growth factor receptor 2 and estrogen and progesterone receptors in mice with breast cancer
Alireza Barari , Jabar Bashiri , Javad Asgari
, alireza54.barari@gmail.com
Abstract:   (4504 Views)

Background: Breast cancer is one of the most common cancers among women in the world in which markers such as human epidermal growth factor receptor 2 (HER-2), estrogen receptors (ER) and progesterone receptors (PR) are considered important prognostic markers. The aim of this study was to investigate the effect of a six-week swimming training program combined with Aloe vera extract on HER-2, ER and PR in mice with breast cancer.

Materials and Methods: The adenocarcinoma tumor implants through surgery in subcutaneously into 35 BALB/c mice and after a week they were divided into five groups: 1-training, 2- extract, 3-training+extract, 4- control (cancer) and 5- healthy control (without training or extract). Training groups performed a swimming training program for six weeks (10-60 minutes swimming, 3 days per week). Blood samples were taken 48 hours after the last bout to be analyzed for serum levels of HER-2, ER and PR.

Results: The results of the present study showed that the induction of adenocarcinoma caused a significant increase in serum levels of HER-2, ER and PR. Moreover, the training program and Aloe vera extract significantly decreased serum levels of HER-2, ER and PR compared to the control group.

Conclusion: These findings are promising regarding the probable potential of both interventions to reduce serum levels of these tumor markers however, it needs to be validated by further studies.

Keywords: Physical exertion, Aloe vera extract, HER-2, Breast cancer
Full-Text [PDF 291 kb]   (1946 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/12/22 | Revised: 2015/12/22 | Accepted: 2015/12/22 | Published: 2015/12/22
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Barari A, Bashiri J, Asgari J. The effect of a six-week swimming training program combined with Aloe vera extract on human epidermal growth factor receptor 2 and estrogen and progesterone receptors in mice with breast cancer. Feyz 2015; 19 (5) :382-390
URL: http://feyz.kaums.ac.ir/article-1-2859-en.html


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This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
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Volume 19, Issue 5 (Bimonthly 2015) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
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