Background: Nausea, vomiting and retching, commonly experienced by women in early pregnancy, have considerable physical and psychological effects on pregnants. This study aimed to examine the effect of acupressure on nausea and vomiting during pregnancy.

Materials and Methods: This single-blind clinical trial was performed on 150 pregnant women (<16 weeks of gestation) referred to Naghavi prenatal clinic for seven days and at two research stages during 2010-11. They were randomly divided into three groups: the acupressure, placebo acupressure and control groups. At first stage, women received no treatment during the first 3 days and on next 4 days a continuous pressure was applied on the P6 point at both wrists using a sea-band in the acupressure and placebo groups. The control group did not receive any intervention. Data were collected by the self-trained women themselves using Rhodes index which then were analyzed statistically.

Results: There was no statistically significant difference among three groups in age, marriage age, gestational age, occupation and satisfaction with spouse. Although the mean change in Rhodes index was not significantly different between the acupressure and placebo groups, the difference was significant between the control and the other two groups.

Conclusion: Acupressure using sea-band is considered as a noninvasive, inexpensive, safe, and effective treatment for the nausea and vomiting during pregnancy.