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:: Volume 14, Number 3 (Quarterly 2010) ::
Feyz 2010, 14(3): 217-222 Back to browse issues page
The effects of different doses of folic acid on motor activity of rat
Maryam Khombi Shooshtari , Mohammad Ali Moazedi, Gholam Ali Parham
, shooshtari_m@yahoo.com
Abstract:   (4563 Views)

Background: Folic acid (folate) which is a water-soluble vitamin-B is essential for the life-sustaining processes of DNA synthesis, replication, repair, and also protein synthesis. Experimental evidence suggests that folate deficiency and its consequent elevated homocysteine level sensitize dopaminergic neurons to environmental toxin, whereby folate deficiency may influence risk of Parkinson disease. Accordingly, in this study, the effects of different doses of folic acid on motor activity of rat were studied using rotarod apparatus.

Materials and Methods: Animals were divided into four groups and were injected intraperitonealy a single dose of folic acid or vehicle/day for one week. The there test groups received 5, 10 and 15 mg/kg/day folic acid and the sham group received saline. Then, all groups were introduced to the rotarod test.

Results: The results showed that 5 mg/kg/day of folic acid significantly improves motor coordination (P<0.05).

Conclusion: Overally, the present results indicate that low-dose folic acid improves motor performance of the rats.

Keywords: Folic acid, Rotarod performance test, Locomotion, Rat
Full-Text [PDF 219 kb]   (1106 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/09/28
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Khombi Shooshtari M, Moazedi M A, Parham G A. The effects of different doses of folic acid on motor activity of rat. Feyz. 2010; 14 (3) :217-222
URL: http://feyz.kaums.ac.ir/article-1-966-en.html
Volume 14, Number 3 (Quarterly 2010) Back to browse issues page
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