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The effect of eight weeks of HIIT training and resveratrol supplementation on serum levels of omentin-1, vaspin, and catalase enzyme in inactive middle-aged obese women
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Sara Sepehrzadeh    , Roghayyeh Afroundeh * , Mohammad Ebrahim Bahram |
| University of Mohaghegh Ardabili , afroundeh@uma.ac.ir |
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Abstract: (8 Views) |
Background: Obesity is associated with chronic inflammation, metabolic dysfunction, and oxidative stress. Adipokines such as omentin-1 and vaspin, along with antioxidant enzymes like catalase, play key roles in these processes. This study aimed to investigate the effects of eight weeks of high-intensity interval training (HIIT) and resveratrol supplementation, separately and in combination, on serum levels of omentin-1, vaspin, and catalase activity in inactive middle-aged obese women.
Materials and Methods: This quasi-experimental study employed a pretest–posttest design with a control group. 40 middle-aged obese women were randomly assigned to four groups: HIIT, resveratrol supplementation, HIIT plus resveratrol, and control. The HIIT program was conducted for eight weeks, three sessions per week, while the supplementation group received 500 mg/day of resveratrol. Blood samples were collected before and 48 hours after the intervention, and serum omentin-1, vaspin, and catalase activity were measured using ELISA. Data were analyzed using analysis of covariance (ANCOVA).
Results: Between-group ANCOVA analyses revealed significant differences among the four groups after the 8-week intervention in serum omentin-1 (F = 42.8, P < 0.001, η² = 0.85), vaspin (F = 31.4, P < 0.001, η² = 0.72), and catalase activity (F = 18.9, P < 0.001, η² = 0.50). Omentin-1 concentrations and catalase activity increased significantly in the exercise and exercise-plus-supplement groups (P = 0.01), whereas vaspin levels showed a significant reduction (P < 0.001). The most pronounced favorable changes were observed in the exercise combined with resveratrol supplementation group.
Conclusion: The combination of HIIT and resveratrol supplementation may effectively improve inflammatory status, regulate adipokines, and enhance antioxidant capacity in middle-aged obese women. This combined exercise–nutritional strategy may represent a promising approach for improving metabolic health in inactive middle-aged obese women.
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| Keywords: Obesity, High-Intensity Interval Training, Resveratrol, Adipokines |
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Type of Study: Research |
Subject:
General
Received: 2026/02/6 | Revised: 2026/07/1 | Accepted: 2026/07/1 | Published: 2026/07/1
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