The Effects of Eight Weeks of High-Intensity Interval Training and Resveratrol Supplementation on Serum Omentin-1, Vaspin, and Catalase Levels in Inactive Middle-Aged Women with Obesity

Sepehrzadeh, sara; afroundeh, Roghayyeh; Bahram, Mohammad Ebrahim

doi:10.48307/FMSJ.2026.30.3.321

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Volume 30, Issue 3 (Bimonthly 2026)

Feyz Med Sci J 2026, 30(3): 321-334

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The Effects of Eight Weeks of High-Intensity Interval Training and Resveratrol Supplementation on Serum Omentin-1, Vaspin, and Catalase Levels in Inactive Middle-Aged Women with Obesity

Sara Sepehrzadeh

, Roghayyeh Afroundeh ^*

, Mohammad Ebrahim Bahram

Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran , afroundeh@uma.ac.ir

Abstract: (434 Views)

Background and Aim: Obesity is associated with chronic inflammation, metabolic dysfunction, and oxidative stress. Adipokines such as omentin‑1 and vaspin, along with the antioxidant enzyme catalase, play important roles in these processes. The aim of this study was to investigate the effects of eight weeks of high‑intensity interval training (HIIT) and resveratrol supplementation, separately and in combination, on serum levels of omentin‑1, vaspin, and catalase activity in inactive middle‑aged obese women.
Methods: This quasi‑experimental study employed a pretest–posttest design with a control group. A total of 40 middle‑aged obese women were randomly assigned to four groups: exercise, supplement, exercise+supplement, and control. The HIIT program was conducted for eight weeks, three sessions per week, and the supplement group received 500 mg/day of resveratrol. Blood samples were collected before and 48 hours after the intervention, and serum levels of omentin‑1, vaspin, and catalase activity were measured using the ELISA method. Data were analyzed using analysis of covariance (ANCOVA).
Results: The results showed that after eight weeks, there were significant differences between the groups in serum levels of omentin‑1 (F=42.8, P<0.001, η²= 0.85), vaspin (F=31.4, P<0.001, η²=0.72), and catalase (F=18.9, P<0.001, η²=0.50). Omentin‑1 levels and catalase activity increased significantly in the exercise and exercise+supplement groups, while vaspin showed a significant reduction (P < 0.001). The most favorable changes were observed in the exercise+supplement group.
Conclusion: The combination of HIIT training and resveratrol supplementation, by improving inflammatory markers, regulating adipokines, and enhancing antioxidant capacity, can be an effective strategy for improving metabolic health in inactive middle‑aged obese women.

Keywords: Obesity, High-Intensity Interval Training (HIIT), Resveratrol, Adipokines

Full-Text [PDF 1166 kb] (32 Downloads)

Type of Study: Research | Subject: General
Received: 2026/02/6 | Revised: 2026/08/25 | Accepted: 2026/07/1 | Published: 2026/07/1

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Sepehrzadeh S, afroundeh R, Bahram M E. The Effects of Eight Weeks of High-Intensity Interval Training and Resveratrol Supplementation on Serum Omentin-1, Vaspin, and Catalase Levels in Inactive Middle-Aged Women with Obesity. Feyz Med Sci J 2026; 30 (3) :321-334
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