The effect of aerobic and resistance training on the inflammatory factor in the kidney tissue of male diabetic Wistar rats

Atashgahian, Rahil; Kashef, Majid; Salehpour, Mojtaba; Eskandari shahrabi, Arezoo

doi:10.48307/FMSJ.2025.29.5.469

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Volume 29, Issue 5 (Bimothly 2025)

Feyz Med Sci J 2025, 29(5): 469-480

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The effect of aerobic and resistance training on the inflammatory factor in the kidney tissue of male diabetic Wistar rats

Rahil Atashgahian

, Majid Kashef ^*

, Mojtaba Salehpour

, Arezoo Eskandari shahrabi

Department of Sports Physiology, Faculty of Sports Sciences, Rajaee Teacher Training University, Tehran, Iran , Kashef@sru.ac.ir

Abstract: (369 Views)

Background and Aim: Diabetic nephropathy is a serious complication of diabetes, characterized by progressive renal inflammation. This study aimed to compare the effects of two different exercise training modalities on the inflammatory marker NF-κB in the renal tissue of diabetic rats.
Methods: In this experimental study, 22 male Wistar rats weighing (180±20 g) were randomly divided into four groups: healthy control, diabetic sham, diabetic+aerobic training, and diabetic+resistance training. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg/kg). The exercise protocols were conducted for six weeks, five days per week. Blood glucose levels were measured using a glucometer, and NF-κB protein expression was quantified via Western blot analysis.
Results: Both exercise training modalities significantly reduced blood glucose levels and the renal inflammatory index NF-κB in the diabetic rats. Specifically, the resistance training group exhibited a reduction in blood glucose from 468±70 mg/dL to 246±83 mg/dL (P=0.001), while the aerobic training group showed a reduction from 377±131 mg/dL to 249±81 mg/dL (P=0.017). Furthermore, NF-κB protein levels decreased significantly post-intervention to 1.07±0.13 in the resistance training group (P=0.018) and to 1.13±0.2 in the aerobic training group (P=0.027). An inter-group analysis showed that resistance training produced a greater reduction in blood glucose compared to aerobic training (P=0.001).
Conclusion: The findings indicate that both aerobic and resistance training are effective in reducing renal inflammation under diabetic conditions. However, resistance training demonstrated more potent glucose-lowering effects. These results underscore the potential of resistance training as a complementary therapeutic strategy in the management of diabetic nephropathy.

Keywords: Diabetes, Resistance training, Aerobic exercise, NF-κB, Renal inflammation

Full-Text [PDF 625 kb] (16 Downloads)

Type of Study: Research | Subject: medicine, paraclinic
Received: 2025/06/22 | Revised: 2025/11/5 | Accepted: 2025/10/13 | Published: 2025/11/3

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Atashgahian R, Kashef M, Salehpour M, Eskandari shahrabi A. The effect of aerobic and resistance training on the inflammatory factor in the kidney tissue of male diabetic Wistar rats. Feyz Med Sci J 2025; 29 (5) :469-480
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