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The effect of aerobic and resistance training on the inflammatory factor of the kidney tissue of male diabetic Wistar rats
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Rahil Atashgahian    , Majid Kashef * , Mojtaba Salehpour , Arezoo Eskandari shahrabi |
| Shahid Rajaei teacher training University , Kashef@sru.ac.ir |
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Abstract: (1 Views) |
Abstract
Background and Aim
Diabetic nephropathy increases the risk of mortality in patients. The aim of the present study was to determine the effect of aerobic and resistance training on the inflammatory factor of the kidney tissue of male diabetic Wistar rats.
Materials and Methods
This study was a developmental study, experimentally and experimentally with a post-test design. 22 male Wistar rats weighing 180±20 g were divided into 4 groups: healthy, sham diabetic, diabetic with aerobic training, diabetic with resistance training. To induce diabetes, streptozotocin 50 mg/kg was injected intraperitoneally as a single dose. The training was performed for 6 weeks, 5 days a week. Blood sugar was measured with a glucometer and NF-κB protein levels were measured by Western blotting. The results were analyzed by one-way ANOVA, t-test and at a P≤0.05 level with SPSS version 25 software.
Results:
The reduction in blood sugar levels in the diabetic group with aerobic exercise from (377±131) to (249±81) mg/dL (P=0.017) and resistance exercise from (468±70) to (246±83) mg/dL was significant (P=0.001), and resistance exercise had a greater effect (P=0.001). The level of NF-κB protein decreased after resistance training (1.07±0.13), (P=0.018) and aerobic training (1.13±0.2), (P=0.027).
Conclusion
Resistance training, like aerobic training, has a similar effect on reducing inflammation in the kidney and has a better effect on reducing blood sugar. Resistance training can be considered as an effective alternative in managing diabetes and reducing inflammation.
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| Keywords: Diabetes, Aerobic and resistance training, Rats, Inflammation, Kidney |
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2025/06/22 | Revised: 2025/10/13 | Accepted: 2025/10/13
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