:: Volume 26, Issue 4 (Bimonthly 2022) ::
Feyz 2022, 26(4): 424-434 Back to browse issues page
Association between adiponectin gene single nucleotide polymorphisms with age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes
Elaheh Mamashli , Farnaz Seifi-Skishahr , Marefat Siahkouhian , Manouchehr IranparvarAlamdari , Asadollah Asadi , Behzad Davarnia *
Department of Medical Genetics and Pathology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, I.R. Iran. , b.davarnia@gmail.com
Abstract:   (276 Views)
Background: The incidence of type 2 diabetes is growing at an early age. Genetic factors probably play an important role in the early onset of type 2 diabetes. The present study aimed to effect of single nucleotide polymorphisms of adiponectin gene rs2241766 (+45 T/G), rs1501299 (+276 G/T) and rs17300539 (-11391G/A) on the age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes.
Materials and Methods: In this case-control study, 183 patients with type 2 diabetes and 155 healthy individuals participated. Demographic and anthropometric data were collected. Genotyping was performed by using amplification refractory mutation system-PCR (ARMS-PCR). Data were analyzed by using SPSS software (version 26).
Results: According to results, in rs2241766 (SNP+45 T/G), the age of onset of diabetes and age of starting insulin therapy in the TG genotype carriers was significantly less than in TT genotype carriers (Respectively P=0.035, P=0.048). In SNP+45 T/G, 48.6% of patients with diabetes onset age<35 years were carrying the TG genotype (P=0.013). TG genotype (OR=2.381, 95% CI:1.430–7.994, P=0.006) was associated with the significantly increased risk of diabetes onset age <35 years.
Conclusion: According to the results of the present study, SNP+45 T/G of the adiponectin gene has a significant effect on the early onset of T2DM as well as the rapid progression of the disease. Evaluation of effective genetic variants can be useful in pre-diabetes screening for early detection and prevention.
Keywords: Adiponectin, Single nucleotide polymorphism, Age of diabetes onset, Age of initiating insulin therapy
Full-Text [PDF 391 kb]   (79 Downloads)    
Type of Study: Applicable | Subject: medicine, paraclinic
Received: 2022/03/28 | Accepted: 2022/07/17 | Published: 2022/09/26
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