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Evaluation of IL-17A rs2275 913 G>A and IL- 17F rs 763780 T>C genes polymorphism in women with breast cancer
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Narges Heshemi, Golnaz Asaadi@yahoo.com *  , Neda Jabara, Kumarss Amini |
| Azad islamic university of zanjan , golnaz_asaadi@yahoo.com |
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Abstract: (666 Views) |
Abstract
Background: Breast cancer is the most common cancer among women around the world, in which mostly is seen in women over 50 years old age. IL-17 which has the main role in responding to inflammation plays role in the early stages of tumorigenic and primary tumor formation. Epidemiological studies have shown that IL-17 is associated with the risk of cancer. This study aimed to investigatory the relationship between single-nucleotide polymorphisms (SNPs) in the IL-17-A rs2275913 G>A and IL-17 F rs763780 T>C genes in women with breast cancer this study.
Materials and Methods: In this research 50 patients and 50 healthy samples were studied as a control group. After genomic DNA extraction, genotype determination of rs2275913 and rs763780 polymorphisms was performed by Tetra- ARMS-PCR method and finally the results statistically were analyzed.
Results: In the current research GG, AG and AA genotype frequencies of IL-17A gene in patient and normal samples were [12(24%), 23(46%),15(30%)] and [21(42%), 27(54%), 2(4%)] respectively, (GA vs GG/AA, OR= 1.49, 95% CI: 0.61-3.67, AA vs GG/GA, OR= 13.12, 95% CI: 2.55-67.46). Also the frequency of an allele in patient and normal population was detected 53% and 31% respectively. IL-17A-197A allele in comparison with G significantly increased risk of breast cancer (OR= 2.510, 95% CI: 1.408-4.473). No significant difference was observed between IL-17 F 7488 T>C gene’s polymorphism and breast cancer’s incidence (OR= 1/000, 95% CI: 0.24-4.24).
Conclusion: The results indicated that IL-17A rs2275913G>A polymorphism was associated with breast cancer in women, which could be effective in the treatment and clinical management of this disease. In contrast, IL-17F rs763780T>C polymorphism did not showed significant association with the susceptibility of breast cancer.
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| Keywords: Breast cancer, polymorphism, IL-17A, IL-17F |
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Full-Text [PDF 952 kb]
(397 Downloads)
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2021/05/20 | Accepted: 2021/10/19 | Published: 2021/11/28
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