[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 25, Issue 5 (Bimonthly 2021) ::
Feyz 2021, 25(5): 1255-1264 Back to browse issues page
Evaluation of IL-17A rs2275 913 G>A and IL- 17F rs 763780 T>C genes polymorphism in women with breast cancer
Narges Heshemi , Golnaz Asaadi@yahoo.com , Neda Jabara , Kumarss Amini
Azad islamic university of zanjan , golnaz_asaadi@yahoo.com
Abstract:   (1031 Views)
Abstract
Background: Breast cancer is the most common cancer among women around the world, in which mostly is seen in women over 50 years old age. IL-17 which has the main role in responding to inflammation plays role in the early stages of tumorigenic and primary tumor formation. Epidemiological studies have shown that IL-17 is associated with the risk of cancer. This study aimed to investigatory the relationship between single-nucleotide polymorphisms (SNPs) in the IL-17-A rs2275913 G>A and IL-17 F rs763780 T>C genes in women with breast cancer this study.
Materials and Methods: In this research 50 patients and 50 healthy samples were studied as a control group. After genomic DNA extraction, genotype determination of rs2275913 and     rs763780 polymorphisms was performed by Tetra- ARMS-PCR method and finally the results statistically were analyzed.
Results: In the current research GG, AG and AA genotype frequencies of IL-17A gene in patient and normal samples were [12(24%), 23(46%),15(30%)]  and [21(42%), 27(54%), 2(4%)] respectively, (GA vs GG/AA, OR= 1.49, 95% CI: 0.61-3.67, AA vs GG/GA, OR= 13.12, 95% CI: 2.55-67.46). Also the frequency of an allele in patient and normal population was detected 53% and 31% respectively. IL-17A-197A allele in comparison with G significantly increased risk of breast cancer (OR= 2.510, 95% CI: 1.408-4.473). No significant difference was observed between IL-17 F 7488 T>C gene’s polymorphism and breast cancer’s incidence (OR= 1/000, 95% CI: 0.24-4.24).
Conclusion: The results indicated that IL-17A rs2275913G>A polymorphism was associated with breast cancer in women, which could be effective in the treatment and clinical management of this disease. In contrast, IL-17F rs763780T>C polymorphism did not showed significant association with the susceptibility of breast cancer.
Keywords: Breast cancer, polymorphism, IL-17A, IL-17F
Full-Text [PDF 952 kb]   (637 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2021/05/20 | Revised: 2021/12/26 | Accepted: 2021/10/19 | Published: 2021/11/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

heshemi N, asaadi@yahoo.com G, jabara N, Amini K. Evaluation of IL-17A rs2275 913 G>A and IL- 17F rs 763780 T>C genes polymorphism in women with breast cancer. Feyz 2021; 25 (5) :1255-1264
URL: http://feyz.kaums.ac.ir/article-1-4401-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 25, Issue 5 (Bimonthly 2021) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645