[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 24, Issue 4 (Bimonthly 2020) ::
Feyz 2020, 24(4): 366-373 Back to browse issues page
The histomorphological effect of Viola odorata flower extract on skin wound healing process in Wistar rats
Ehsan Sedghi , Elham Moghtadaei-Khorasgani , Mostafa Norbakhsh
Graduate of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, I.R. Iran. , MOGHTADAIEE@GMAIL.COM
Abstract:   (2298 Views)
Background: Wound healing is an important concern that humankind is facing and attempting to find compounds that have the least side effects on wound healing is important. Since violet flower extract has anti-inflammatory and disinfection effects, in this study the impact of this plant on wound healing was examined.
Materials and Methods: 32 rats were provided from the laboratory animal breeding center in Shahrekord, and after anesthetizing them, a full-thickness skin wound was created by a 2 by 2 Cm stencil in the posterior cervical region. The control group received no treatment, one group received Eucerin, another group received Silver Sulfadiazine 1% and the experimental group received ointment of violet flower extract 20% twice a day. Throughout the study, the length and width of the wounds were measured in each group every three days. On the 3rd, 7th, 14th and 21st days after creating the wound, the rats were anesthetized and the healed tissues were examined for histopathologic studies.
Results: The results showed a significant reduction in wound area in treated animals, especially violets, compared with the control group (P<0.05). Histopathologically, the thickness of the epithelium and the amount of collagen showed a significant increase in the experimental group of violets.
Conclusion: This can probably be attributed to the anti-inflammatory effects of the effective components of violet flower. also it’s likely that these components stimulate collagen production and quicker contraction of wounds. Therefore, the compounds of this plant can be used to treat wounds.
Keywords: Skin wound, Healing, Violet flower extract, Rat
Full-Text [PDF 1589 kb]   (750 Downloads)    
Type of Study: Applicable | Subject: medicine, paraclinic
Received: 2019/12/23 | Revised: 2020/11/7 | Accepted: 2020/09/9 | Published: 2020/10/10
References
1. Clark RA. Biology of dermal wound repair. Dermatol Clin 1993; 11(4): 647-66.
2. Allah Tavakoli M, Khaksari Haddad M, Assar S. Comparison of topical application of Mummify and Phenytoin cream on skin wound healing in rat. JBUMS 2003; 5(2): 7-13. [in Persian]
3. Ramezani M, Zarrinkamar F, Bagheri M, Rajabnia R. Study of Environment Temperature Effect on the Antibacterial Activity of water extract of different organs of Viola Odorata in the different stages of growth. JBUMS 2012; 14(2): 16-21. [in Persian]
4. Farahpour MR, Sedaghat S. Effect of Malva sylvestris hydroethanolic leaf extract on the healing of full-thickness, excisional skin wound in the rat JVCP 2015; 9(33): 73-89. [in Persian]
5. Hoseini-Tahmasbi M, Hoseini-Tahmasbi S, Karami-dehkordi A, Delaram M, MalekAnzabi J, Fatahi F. Effect of Arnebia euchroma root extract on burn wound healing in Balb/c mice. JSUMSi 2013; 15(4): 54-61. [in Persian]
6. Ghorbani A, Javadi Youssofabad N, Rakhshandeh H. Effect of Viola tricolor on pentobarbital-induced sleep in mice. Afr J Pharm Pharmacol 2012; 6(323): 2503-9. [in Persian]
7. Rafiee-Vardanjani L, Sahinfard N, Rahimi-Madiseh M. Effect of Portulaca Oleracea L vice versa silver sulfadiazine on burn wound healing in Balb/c Mice. JSUMS 2012; 13(6): 92-100. [in Persian]
8. Alahtavakoli R, Vazirinejad M. Effect of Teucrium polium extract on skin wound healing in rat. HMJ 2012; 16(1): 17-24. [in Persian]
9. Alipanah H, Bigdeli MR, Esmaeili MA, Akbari ME. Effect of viola odorata extract on cell survival of triple negative breast cancer MDA-MB-468 cells, JMUMS 2015; 25(132): 186-99. [in Persian]
10. Abbaspour H, khaksari M. Topical effectiveness of kiwifruit on burn wound healing in male rats. NKUMS 2013; 5(1): 91-7. [in Persian]
11. Alipanah H, Bigdeli MR, EsmaeiliMM A, Mohammad Esmaeil Akbari M. Effect ofViola odorataExtract on Cell Survival of Triple Negative Breast Cancer MDA-MB-468 Cells. JMUMS 2015; 25(132): 186-99. [in Persian]
12. Rezvanipour M, Hosseini F, Pourafshar R, Zarabi A. The effect of mummies on some of the indices involved in wound healing in mice. JKMU 2007; 14(4): 267-77. [in Persian]
13. Zarabi M, Roshan A, Asgarani E, Pakdel M, Rouini M. The identification of gene coding cyclotide from Viola Species and investigation of antimicrobial activities of extracted cyclotides. HBB 2017; 24(2): 89-96. [in Persian]
14. Blac J, Hawks J. H. Medical surgical nursing: Clinical management for positive outcomes .8th ed. St. Louis 2008, p. 2010.
15. Nasiri A, Hosseini J, Azadbakht M. Treatment of burn wound treatment based on traditional folk and oral medicinet Through asteri in mazandaran province. JMP 2013; 48(12): 136-49. [in Persian]
16. Yaghmayei P, Moshrefjavadi F, Nilforooshzade MA, Mardani H, Kadanejadian P. The effect of 2% alcohol green tea extract on healing process of open wound in male mice. JIMS 2009; 96(27): 324-35. [in Persian]
17. Boswell C, Cannon S, Miller J. Students’ perceptions of holistic nursing care. NEP 2013; 34(5): 329-33.
18. Brunner L, Smeltzer S, Bare BL, Hinkle P, Kerry H. suddarth's textbook of medical-surgical nursing. Philadelphia: Williams and Wilkins. 12th ed, 2010, p. 1980-2002.
19. Asadi S, Zamiri A, Ezzati S, Parsaei P, Rafieian M, Shirzad H. Effect of alcoholic extract of green tea (Camellia sinensis) on the healing process in surgical and burn wounds in rats. JBUMS 2011; 18(1): 1-9. [in Persian]
20. Norbakhsh M, Sadeghi A, Ahmadi M. Study of Nigella Sativa L. Seeds hydroethanolic extract on skin wound healing in rat. IVSC12 2018, Semnan university, Iran. p113. [in Persian]
21. Davari S, Hajinezhad M, Samadi K, Eftekhari S. The Effect of Calendula, Aloe and Caster on Cutaneous Wounds Healing Process in Mature Male Rat. JRUMS 2018; 17(2): 93-104. [in Persian]
22. Bibak B, Bahmanyar S, Feizi P, Zarghami Moghaddam P, Alesheykh P. Survey of antibacterial effect from different extractsof Viola Odrata on three chronic sinusitis bacteria. NKUMS 2014; 6(4): 727-34. [in Persian]
23. Ulkur E. Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and fusidic acid 2% (Fucidin) for topical antibacterial effect in methicillin-resistant Staphylococci-contaminated, full-skin thickness rat burn wounds. BURNS 2005; 31(7): 874-7.
24. Broughton G, Jeffery E. Basic Science of wound healing surgery. PRS 2006; 117(7): 125-345.
25. Shetty S, Udupa L. Evaluation of Antioxidant and wound healing effect of alcoholic and aqueous extract of Ocimum Sanctum linn in rats. eCAM 2008; 5(1): 95-101.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sedghi E, Moghtadaei-Khorasgani E, Norbakhsh M. The histomorphological effect of Viola odorata flower extract on skin wound healing process in Wistar rats. Feyz 2020; 24 (4) :366-373
URL: http://feyz.kaums.ac.ir/article-1-4050-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 24, Issue 4 (Bimonthly 2020) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 46 queries by YEKTAWEB 4645