:: Volume 24, Issue 5 (Bimonthly 2020) ::
Feyz 2020, 24(5): 491-498 Back to browse issues page
The study of the effect of 8 weeks of interval activity on angiogenesis indexes and cardiovascular risk factor in high-fat diet mice
Somayeh Azizi , Mohammad Fathi , Vahid Valipour , Somayeh Ahmadabadi
Department of Physical Education and Sport Sciences, Faculty of Human Sciences, Lorestan University, Khoramabad, I.R. Iran. , fathi.m@lu.ac.ir
Abstract:   (1844 Views)
Background: Physical activity has a positive effect on angiogenesis and inflammation indexes, but its effect on people who intake a high-fat diet is not clear. Therefore, this study aimed to determine the effect of 8 weeks of interval activity on serum levels of angiogenesis factors and inflammatory index predicting cardiovascular disease on high-fat diet rats.
Materials and Methods: In this experimental study, 30 male Wistar rats (6 weeks old) were randomly assigned in 3 groups; normal diet (n=10), high-fat diet (n=10), and high-fat diet-interval training. For the first and second groups, the training program was performed 5 days a week for 8 weeks. Before the first session and 48 hours after the last session of physical activity, blood samples were taken using the ELISA method to examine NO, VEGF, and CRP. the MANOVA test was used to analyze data
Results: The results of this study showed that 8 weeks of interval training increased significantly (p<0.0001) NO and VEGF (P=0.0001) levels in the high-fat diet-interval training group compared to the control group and high-fat diet group. However, the CRP level of the high-fat diet-interval training group decreased significantly (P=0.0001) than the control group.
Conclusion: according to the findings of this study, 8 weeks of interval training increase some angiogenesis factors such as NO and VEGF, which results in the probable reduction of CRP as a risk factor of cardiovascular disease.
Keywords: Interval training, Cardiovascular risk factors, Angiogenesis, High-fat diet
Full-Text [PDF 790 kb]   (759 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2019/11/13 | Revised: 2020/12/15 | Accepted: 2020/10/4 | Published: 2020/12/15
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