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:: Volume 24, Issue 5 (Bimonthly 2020) ::
Feyz Med Sci J 2020, 24(5): 491-498 Back to browse issues page
The study of the effect of 8 weeks of interval activity on angiogenesis indexes and cardiovascular risk factor in high-fat diet mice
Somayeh Azizi , Mohammad Fathi * , Vahid Valipour , Somayeh Ahmadabadi
Department of Physical Education and Sport Sciences, Faculty of Human Sciences, Lorestan University, Khoramabad, I.R. Iran. , fathi.m@lu.ac.ir
Abstract:   (2051 Views)
Background: Physical activity has a positive effect on angiogenesis and inflammation indexes, but its effect on people who intake a high-fat diet is not clear. Therefore, this study aimed to determine the effect of 8 weeks of interval activity on serum levels of angiogenesis factors and inflammatory index predicting cardiovascular disease on high-fat diet rats.
Materials and Methods: In this experimental study, 30 male Wistar rats (6 weeks old) were randomly assigned in 3 groups; normal diet (n=10), high-fat diet (n=10), and high-fat diet-interval training. For the first and second groups, the training program was performed 5 days a week for 8 weeks. Before the first session and 48 hours after the last session of physical activity, blood samples were taken using the ELISA method to examine NO, VEGF, and CRP. the MANOVA test was used to analyze data
Results: The results of this study showed that 8 weeks of interval training increased significantly (p<0.0001) NO and VEGF (P=0.0001) levels in the high-fat diet-interval training group compared to the control group and high-fat diet group. However, the CRP level of the high-fat diet-interval training group decreased significantly (P=0.0001) than the control group.
Conclusion: according to the findings of this study, 8 weeks of interval training increase some angiogenesis factors such as NO and VEGF, which results in the probable reduction of CRP as a risk factor of cardiovascular disease.
Keywords: Interval training, Cardiovascular risk factors, Angiogenesis, High-fat diet
Full-Text [PDF 790 kb]   (843 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2019/11/13 | Revised: 2020/12/15 | Accepted: 2020/10/4 | Published: 2020/12/15
References
1. Esfahani M, Baranchi M, Ataei N, Goodarzi MT. The role of adipokines in the pathophysiology of cardiovascular diseases. RJMS 2017; 24(157). [in Persian]
2. Shirvani H, Soleimani M, Sanayinasab H, Rahmati-Ahmadabad S. A Review on the Effect of Exercise on Obesity by Modulating the Immune System and Toll-Like Receptors. Mil Med 2018; 20(5): 456-75. [in Persian]
3. Lemoine AY, Ledoux S, Larger E. Adipose tissue angiogenesis in obesity. JTH 2013; 110(10): 661-9.
4. Corvera S, Gealekman O. Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta 2014; 1842(3): 463-72.
5. Weston KS, Wisløff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med 2014; 48(16): 1227-34.
6. Kazemi A. Effect of high intensity interval training on visceral and subcutaneous levels of MCP-1 and plasma insulin and glucose in male rats. RJMS 2017; 23. [in Persian]
7. Habibi Maleki A, Tolouei Azar J, Ghaderi Pakdel F, Tofighi A. the effect of 12 weeks of moderate intensity continuous training (mict) on inflammatory and angiogenesis factors of visceral and subcutaneous adipose tissue in obese rats: a semi-experimental study. UMJ 2019; 30(4): 300-14. [in Persian]
8. Nourshahi M, Taheri Chadorneshin H, Ranjbar K. The stimulus of angiogenesis during exercise and physical activity. HMS 2013; 18(5): 286-96. [in Persian]
9. Tofighi A, Asemi A, Heydarzade A. Relationship between BMI and Blood CRP and Fibrinogen in Obese, Thin and Normal Weight among Girl Students. Qom University Med Sci J 2012; 6(2): 82-7. [in Persian]
10. Kruger HS. Associations of serum C-reactive protein with physical activity, fitness and fatness in South African adolescents. Cardiovasc J Afr 2010; 21(6): 309.
11. Kwak SE, Lee JH, Zhang D, Song W. Angiogenesis: focusing on the effects of exercise in aging and cancer. JENB 2018; 22(3): 21.
12. Landers-Ramos RQ, Corrigan KJ, Guth LM, Altom CN, Spangenburg EE, Prior SJ, et al. Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults. Applied Physiology. Nutr Metab Cardiovasc Dis 2016; 41(8): 832-41.
13. Zamani S, Neyestani T, Kalayi A, Alavimajd H, Hoshyarrad A, Nikooyeh B, et al. Determinants of inflammation and systolic blood presure in women with central obesity: a cross-sectional study. IJNSFT 2011; 6(2): 1-10.
14. Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, et al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50–60 years. BJSM 2008; 42(2): 126-9.
15. Mohammadi R, Fathei M, Hejazi K. Effect of Eight-Weeks Aerobic Training on Serum Levels of Nitric Oxide and Endothelin-1 in Overweight Elderly Men. IJA 2018; 13(1): 74-85. [in Persian]
16. Krause M, Rodrigues-Krause J, O’Hagan C, Medlow P, Davison G, Susta D, et al. The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production. Eur J Appl Physiol Occup Physiol 2014; 114(2): 251-60.
17. Tangvarasittichai S, Pongthaisong S, Tangvarasittichai O. Tumor necrosis factor-Α, interleukin-6, C-reactive protein levels and insulin resistance associated with type 2 diabetes in abdominal obesity women. Indian J Clin Biochem 2016; 31(1): 68-74.
18. Villelabeitia-Jaureguizar K, Vicente-Campos D, Senen AB, Jiménez VH, Garrido-Lestache MEB, Chicharro JL. Effects of high-intensity interval versus continuous exercise training on post-exercise heart rate recovery in coronary heart-disease patients. Int J Cardiol 2017; 244: 17-23.
19. Fallahi A, Gaeini A, Shekarfroush S, Khoshbaten A. Cardioprotective effect of high intensity interval training and nitric oxide metabolites (NO2−, NO3−). IJPH 2015; 44(9): 1270 [in Persian]
20. Prior BM, Yang H, Terjung RL. What makes vessels grow with exercise training? J Appl Physiol 2004; 97(3): 1119-28.
21. Taghian F. Homocystein and C-reactive protein response to acute training in obese and non-obese females. Quarterly Ofoghe Danesh 2012; 18(3): 129-34. [in Persian]
22. Kasraei H, Kargaefard M, Nazarali P, Nobari H, Zare A. the effects of combined exercise with and without diet on plasma inflammatory biomarkers and endothelialys function in elderly patients with type 2 diabetes. IJDM 2019; 18(4): 207-20. [in Persian]
23. Buettner R, Parhofer K, Woenckhaus M, Wrede C, Kunz-Schughart L, Scholmerich J, et al. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. Mol Endocrinol 2006; 36(3): 485-501.
24. Batacan Jr RB, Duncan MJ, Dalbo VJ, Connolly KJ, Fenning AS. Light-intensity and high-intensity interval training improve cardiometabolic health in rats. Appl Physiol Nutr Metab 2016; 41(9): 945-52.
25. Tang K, Xia FC, Wagner PD, Breen EC. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. RESPNB 2010; 170(1): 16-22.
26. Wahl P, Jansen F, Achtzehn S, Schmitz T, Bloch W, Mester J, et al. Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors. PLoS One 2014; 9(4): e96024.
27. Hoier B, Nordsborg N, Andersen S, Jensen L, Nybo L, Bangsbo J, et al. Pro‐and anti‐angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol 2012; 590(3): 595-606.
28. Sanders GS, Baron RS. The motivating effects of distraction on task performance. J Personality Social Psychol 1975; 32(6): 956.
29. Gavin TP, Wagner PD. Effect of short-term exercise training on angiogenic growth factor gene responses in rats. J Appl Physiol 2001; 90(4): 1219-26.
30. Sanchez AM. FoxO transcription factors and endurance training: a role for FoxO1 and FoxO3 in exercise-induced angiogenesis. J Physiol 2015; 593(Pt 2): 363.
31. Olfert IM, Baum O, Hellsten Y, Egginton S. Advances and challenges in skeletal muscle angiogenesis. American Am J Physiol Heart Circ 2016; 310(3): H326-H36.
32. Molla HF, Bizheh N, Moazami M, Nourshahi M. the effects of eight weeks aerobic training on angiogenes factor and body composition in overweight women. J Sport Exerc Psychol 2016; 9(2): 1365-74.
33. Edwards DG, Schofield RS, Lennon SL, Pierce GL, Nichols WW, Braith RW. Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol 2004; 93(5): 617-20.
34. Güzel NA, Hazar S, Erbas D. Effects of different resistance exercise protocols on nitric oxide, lipid peroxidation and creatine kinase activity in sedentary males. J Sports Sci Med 2007; 6(4): 417.
35. Taqwa Al-Husseini SJ. Control of skeletal muscle blood flow by nitric oxide derived from endothelial cells following physical and athletic activity. Olympic 2003; 9: 85-92.
36. Milani RV, Lavie CJ, Mehra MR. Reduction in C-reactive protein through cardiac rehabilitation and exercise training. J Am Coll Cardiol 2004; 43(6): 1056-61.
37. Heffernan KS, Jae SY, Vieira VJ, Iwamoto GA, Wilund KR, Woods JA, et al. C-reactive protein and cardiac vagal activity following resistance exercise training in young African-American and white men. American. Am J Physiol 2009; 296(4): R1098-R105.
38. Tsukiyama Y, Ito T, Nagaoka K, Eguchi E, Ogino KJJoCB. Effects of exercise training on nitric oxide, blood pressure, and antioxidant enzymes. J Clin Biochem Nutr. 2017:16-108.
39. Swift DL, Johannsen NM, Earnest CP, Blair SN, Church TS. The effect of exercise training modality on C-reactive protein in Type-2 diabetes. MSSE 2012; 44(6): 1028.
40. Moeller K, Ostermann AI, Rund K, Thoms S, Blume C, Stahl F, et al. Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and oxylipins in obese subjects. Prost, Leuk Med Ess Fat Aci 2016; 106: 39-49.
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Azizi S, Fathi M, Valipour V, Ahmadabadi S. The study of the effect of 8 weeks of interval activity on angiogenesis indexes and cardiovascular risk factor in high-fat diet mice. Feyz Med Sci J 2020; 24 (5) :491-498
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Volume 24, Issue 5 (Bimonthly 2020) Back to browse issues page
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