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:: Volume 22, Issue 4 (Bimonthly 2018) ::
Feyz 2018, 22(4): 379-386 Back to browse issues page
Association of adiponectin rs17300539 gene polymorphism with a non-alcoholic fatty liver disease in an Iranian population
Fahimeh Rezaei , Masoumeh Nezhadali * , Mehdi Hedayati
Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, I. R. Iran. , ma_nejadali@yahoo.com
Abstract:   (1547 Views)

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, resulting from exceeding fat cumulating in the liver .Adiponectin, a protein secreted from the adipose tissue, reduces liver inflammation. In this study, the relationship between adiponectin rs17300539 gene polymorphism and a non-alcoholic fatty liver disease was investigated.
Materials and Methods: This case-control study was conducted on 80 subjects with NAFLD and 80 healthy subjects. The determination of polymorphism rs17300539 of adiponectin gene was performed by the PCR-RFLP method and electrophoresis technique. The plasma levels of adiponectin and insulin hormones were measured by an enzyme-linked immunosorbent assay (ELISA) kit.
Results: The results showed that there was no significant difference in allele frequencies between the two groups of the case and control (P>0.05). The body mass index (BMI) in genotype GA carriers was higher than that of genotype GG carriers (P<0.05). Moreover, the diastolic blood pressure in the male patients carrying the genotype GA was higher than that in the genotype GG carriers (P<0.05). In the female patients carrying the genotype GA, the AST and triglyceride levels were higher than the GG female carriers (P<0.05). 
Conclusion: It seems that the allele G can be beneficial in reducing the side-effects of the non-alcoholic fatty liver disease.
Keywords: Non-alcoholic fatty liver, Adiponectin, Polymorphism, Adipose tissue
Full-Text [PDF 264 kb]   (398 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/11/8 | Accepted: 2018/06/20 | Published: 2018/10/6
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Rezaei F, Nezhadali M, Hedayati M. Association of adiponectin rs17300539 gene polymorphism with a non-alcoholic fatty liver disease in an Iranian population. Feyz. 2018; 22 (4) :379-386
URL: http://feyz.kaums.ac.ir/article-1-3463-en.html

Volume 22, Issue 4 (Bimonthly 2018) Back to browse issues page
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