[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: ::
Back to the articles list Back to browse issues page
Relationship between Adiponectin gene polymorphism in rs 17300539 with non-alcoholic fatty liver disease in Iranian population
Fahimeh Rezaei , Masoumeh Nezhadali * , Mehdi Hedayati
Assistant Professor Islamic Azad University , ma_nejadali@yahoo.com
Abstract:   (177 Views)
Background: Non-alcoholic fatty liver disease (NAFLD) is a big challenge in recent years and along with changes such as, steatosis, steatohepatitis and cirrhosis. There is evidence that adiponectin, a protein secreted from adipose tissue, adiponectin reduces liver inflammation and fibrosis. Genetic factors are involved in the progression of fatty liver. Therefore, in this study, the relationship between adiponectin gene polymorphism rs17300539 and no- alcoholic fatty liver disease was investigated.
Materials and methods: this case-control study on 80 person with NAFLD and 80 person healthy. Determine polymorphism rs17300539 of adiponectin gene was performed by method PCR – RFLP and electrophoresis technique. The leves of adiponectin and insulin hormone were performed by a kit of company Mercodia Sweden. The rest variables were measured by the Pars azmoon kit.
Results: there was a significant difference in the frequency of the G allele between the two gropes of cases and control (P = 0.034). The BMI of genotype GG carriers was higher than that of genotype GA carriers (P = 0.034). The diastolic pressure in the patient and the male patient carrying the genotype GA was higher than the genotype GG carriers (P = 0.05). In the female patients carrying genotype GA, Total Cholesterol levels and AST higher than carrier GG (P = 0.025, P= 0.09).  
Conclusion: In this study, the results were obtained in patients with non – alcoholic fatty liver disease, in genotype GA, BMI in patients with GA and in women carrying genotype GA had diastolic pressure level, cholesterol and AST levels more than carriers GG. Therefore, the allele G is more favorable.
Keywords: non-alcoholic fatty liver disease, adiponectin, polymorphism
     
Type of Study: Research | Subject: General
Received: 2017/11/8 | Accepted: 2018/06/20
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print



Back to the articles list Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3752