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:: Volume 22, Issue 2 (Bimonthly 2018) ::
Feyz 2018, 22(2): 128-133 Back to browse issues page
The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats
Sephdeh Hasani , Masoumeh Habibian *
Department of Physical Education, Qaemshahar Branch, Islamic Azad University, Qaemshahar, I. R. Iran. , habibian_m@yahoo
Abstract:   (274 Views)
Background: The aging process is associated with a progressive deterioration of tissues and organs. Apoptotic cell death has been known as a possible causal factor in age-related pathologies. Therefore, this study was conducted to assess the effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of aged female rats.
Materials and Methods: In this experimental study, 14 aged female Wistar rats were selected and randomly divided into two equal groups (n=7) of control and exercise. The animals performed 10 bouts of 1-min high-intensity treadmill running (20–34 m·min–1), separated by 2 min of rest, for 3 days a week for 8 weeks. The rats were killed 48 h after the last treatment and their brain Bax and Bcl-2 levels were evaluated by the ELISA method.
Results: The results showed that an 8-week, high-intensity interval exercise decreased brain Bax levels in aged rats (P<0.05). However, a significant increase was observed in the levels of brain Bcl-2 in the exercise group (P<0.05).
Conclusion: It seems that a high-intensity exercise may mediate part of its protective effect against aging-induced apoptosis, by increasing brain Bcl-2 and suppressing Bax levels in brain.
Keywords: Apoptotic, Brain, High-intensity interval training
Full-Text [PDF 198 kb]   (65 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/09/22 | Accepted: 2018/02/24 | Published: 2018/03/19
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Hasani S, Habibian M. The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats. Feyz. 2018; 22 (2) :128-133
URL: http://feyz.kaums.ac.ir/article-1-3437-en.html

Volume 22, Issue 2 (Bimonthly 2018) Back to browse issues page
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