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:: Volume 21, Issue 2 (Bimonthly 2017) ::
Feyz 2017, 21(2): 110-117 Back to browse issues page
Ameliorative effect of lithium chloride on working and spatial memory deficit in a PTZ-induced seizure model
Marzieh Yazdani, Mohammad Amin Edalatmanesh *, Samaneh Rafiei
Department of Physiology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, I. R. Iran. , amin.edalatmanesh@gmail.com
Abstract:   (2673 Views)

Background: The repetitive seizure attacks lead to widespread neuronal damage and cognitive deficit, e.g. memory and learning impairment. The single or repeated administration of pentylenetetrazole (PTZ) can induce seizure in rat. This study evaluates the neuroprotective effect of lithium chloride (LiCl) on PTZ-induced working and spatial memory deficit.

Materials and Methods: To induce the PTZ-kindling model, repeated doses of PTZ (40mg/kg/BW/ip) were injected for 5 consecutive days. After observing five stages of seizure, the PTZ+Li20, PTZ+Li40 and PTZ+Li80 groups received 20, 40 and 80 mg/kg/BW of LiCl, respectively and the PTZ+Saline group, received Saline for 14 days. The Morris water maze (MWM) and Y maze tests were conducted in order to investigate the spatial and working memory. 

Results: Compared to Control group, the PTZ+Saline group showed a decrease in alteration behavior in Y maze and an increase in latency time and distance to hidden platform in MWM. LiCl-treated rats, especially in the lowest dose, showed a significant higher alteration behavior in Y maze and the lower latency time and distance to hidden platform in MWM than the PTZ+Saline group.  

Conclusion: The neuroprotective effects of LiCl can ameliorate the spatial and working memory impairment in a PTZ-kindling model.

Keywords: Seizure, Cognitive disorders, Lithium, Rat
Full-Text [PDF 325 kb]   (991 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/05/22 | Accepted: 2017/05/22 | Published: 2017/05/22
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Yazdani M, Edalatmanesh M A, Rafiei S. Ameliorative effect of lithium chloride on working and spatial memory deficit in a PTZ-induced seizure model. Feyz. 2017; 21 (2) :110-117
URL: http://feyz.kaums.ac.ir/article-1-3339-en.html

Volume 21, Issue 2 (Bimonthly 2017) Back to browse issues page
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