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:: دوره 21، شماره 1 - ( دوماه نامه 1396 ) ::
جلد 21 شماره 1 صفحات 42-50 برگشت به فهرست نسخه ها
اثر موضعی آلندرونات سدیم همراه با جرم‌گیری و تسطیح سطح ریشه در مصرف کنندگان سیگار مبتلا به پریودنتیت مزمن: یک مطالعه پایلوت
فرین کیانی، هاشم منتصری، صدف ادیبی، مسعود گل شاه، صبا گل شاه*
دانشجوی دندانپزشکی کمیته تحقیقات دانشجویی، دانشکده دندانپزشکی، دانشگاه علوم پزشکی شیراز ، saba0_0@yahoo.com
چکیده:   (1019 مشاهده)

سابقه و هدف: درمان­ های شیمیایی جهت تعدیل پاسخ میزبان به­ عنوان روش کمکی، همراه با درمان­ های مکانیکی در درمان پریودنتیت به ­کار می­ روند. هدف از انجام این مطالعه بررسی اثر موضعی ژل آلندرونات سدیم همراه با جرم­گیری و تسطیح سطح ریشه روی شاخص ­های پریودنتال و ساخت استخوان در ضایعات پریودنتال عمودی مصرف کنندگان سیگار مبتلا به پریودنیت مزمن بود.

مواد و روش ­ها: در این مطالعه پایلوت تعداد 8 ضایعه عمودی استخوانی با عمق بیش از 5 میلی­ متر در مصرف کنندگان سیگار مورد مطالعه قرار گرفتند. پس از انجام فاز یک درمان پریودنتال، ژل آلندرونات سدیم یک درصد در پاکت­ های پریودنتال قرار داده شد و این عمل 4 هفته بعد دوباره تکرار شد. شاخص ­های پریودنتال شامل ایندکس پلاک، ایندکس خونریزی، عمق پاکت، میزان تحلیل لثه و هم­ چنین پارامتر رادیوگرافی (عمق ضایعه استخوانی) در ابتدا و 6 ماه پس از قرار دادن ژل آلندرونات سدیم درون ضایعات عمودی استخوان اندازه­ گیری شدند.

نتایج: شاخص عمق پاکت (0/026=P)، خونریزی حین پروبینگ (0/007=P) و ایندکس پلاک (0/007=P) و شاخص عمق ضایعه استخوان (0/012=P) پس از درمان با ژل آلندرونات سدیم نسبت به قبل از درمان کاهش معنی­ داری را نشان داد و شاخص تحلیل لثه (0/011=P) افزایش معنی­ داری را نسبت به قبل از مداخله نشان داد.

نتیجه گیری: استفاده موضعی از ژل آلندرونات سدیم یک درصد نقش به­سزایی در بهبود شاخص ­های پریودنتال و ساخته شدن استخوان در ضایعات عمودی مصرف کنندگان سیگار مبتلا به پریودنتیت مزمن دارد.

واژه‌های کلیدی: پریودنتیت مزمن، آلندرونات، ایندکس پریودنتال، تحلیل استخوان آلوئول، استعمال دخانیات
متن کامل [PDF 212 kb]   (325 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: ۱۳۹۵/۱۲/۹ | پذیرش: ۱۳۹۵/۱۲/۹ | انتشار: ۱۳۹۵/۱۲/۹
فهرست منابع
1. Kiani Yazdy F, Golshah M, Razmkhah M, Ghadery A. Apoptosis of gingival connective tissue cells in diabetic individuals with chronic periodontitis. J Dental Med 2013; 26(2): 99-107.
2. Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza's Clinical Periodontology. St. Louis: Elsevier; 2012. p. 41-45, 294-301.
3. Shivanaikar SS, Faizuddin M, Bhat K. Effect of smoking on neutrophil apoptosis in chronic periodontitis: an immunohistochemical study. Indian J Dent Res 2013; 24(1): 147.
4. Anil S, Vellappally S, Preethanath RS, Mokeem SA, AlMoharib HS, Patil S, et al. Hepatocyte growth factor levels in the saliva and gingival crevicular fluid in smokers with periodontitis. Dis Markers 2014; 2014: 146974.
5. Gamonal J, Sanz M, O'Connor A, Acevedo A, Suarez I, Sanz A, et al. Delayed neutrophil apoptosis in chronic periodontitis patients. J Clin Periodontol 2003; 30(7): 616-23.
6. Crawford JM, Wilton JM, Richardson P. Neutrophils die in the gingival crevice, periodontal pocket, and oral cavity by necrosis and not apoptosis. J Periodontol 2000; 71(7): 1121-9.
7. Nociti FH Jr, Casati MZ, Duarte PM. Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontol 2000. 2015; 67(1): 187-210.
8. Mokeem SA, Vellappally S, Preethanath RS, Hashem MI, Al-Kheraif AA, Anil S. Influence of smoking on clinical parameters and gingival crevicular fluid volume in patients with chronic periodontitis. Oral Health Dent Manag 2014; 13(2): 469-73.
9. Nishida N, Tanaka M, Hayashi N, Nagata H, Takeshita T, Nakayama K, et al. Determination of smoking and obesity as periodontitis risks using the classification and regression tree method. J Periodontol 2005; 76(6): 923-8.
10. Nassrawin NA. Effect of smoking on the response to nonsurgical periodontal therapy. East Mediterr Health J 2010; 16(2): 162-5.
11. Aimetti M. Nonsurgical periodontal treatment. Int J Esthet Dent 2014; 9(2): 251-67.
12. Rajan P, Baramappa R, Rao NM, Pavaluri AK, P I, Rahaman SM. Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. J Clin Diagn Res 2014; 8(12): ZC11-4.
13. Yao W, Xu P, Pang Z, Zhao J, Chai Z, Li X, et al. Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs. Int J Nanomedicine 2014; 9: 3963-70.
14. Yao W, Xu P, Pang Z, Zhao J, Chai Z, Li X, et al. Systemic metronidazole in the treatment of periodontitis. J Clin Periodontol 1989; 16(7): 443-50.
15. Buduneli E, Vardar S, Buduneli N, Berdeli AH, Turkoglu O, Baskesen A, et al. Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. J Periodontol 2004; 75(11): 1516-23.
16. Sigusch B, Beier M, Klinger G, Pfister W, Glockmann E. A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. J Periodontol 2001; 72(3): 275-83.
17. Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, et al. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 2005; 32(10): 1096-107.
18. Kaner D, Christan C, Dietrich T, Bernimoulin JP, Kleber BM, Friedmann A. Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. J Periodontol 2007; 78(7): 1201-8.
19. Baltacioglu E, Aslan M, Sarac O, Saybak A, Yuva P. Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. J Can Dent Assoc 2011; 77: b97.
20. Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/ metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis. J Periodontol 2012; 83(6): 731-43.
21. Aimetti M, Romano F, Guzzi N, Carnevale G. Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. J Clin Periodontol 2012; 39(3): 284-94.
22. Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 2008; 35(10): 885-96.
23. Keestra JA, Grosjean I, Coucke W, Quirynen M, Teughels W. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: a systematic review and meta-analysis. J Periodontal Res 2015; 50(6): 689-706.
24. Bidault P, Chandad F, Grenier D. Systemic antibiotic therapy in the treatment of periodontitis. J Can Dent Assoc 2007; 73(6): 515-20.
25. Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002; 29 Suppl 3: 136-59.
26. Schmidt E, Kaciroti N, Loesche W. Benefits of additional courses of systemic azithromycin in periodontal therapy. Gen Dent 2011; 59(3): 180-7.
27. Bhatia M, Urolagin SS, Pentyala KB, Urolagin SB, K BM, Bhoi S. Novel therapeutic approach for the treatment of periodontitis by curcumin. J Clin Diagn Res 2014; 8(12): ZC65-9.
28. Newman MG, Takel HH, Klokkevold PR, Carranza FA. Antiinfective Therapy. Carranza's Clinical Periodontology. 11 ed. China: Linda Duncan; 2012. p. 482-91.
29. Needleman IG, Pandya NV, Smith SR, Foyle DM. The role of antibiotics in the treatment of periodontitis (Part 2--Controlled drug delivery). Eur J Prosthodont Restor Dent 1995; 3(3): 111-7.
30. Kinane DF. Local antimicrobial therapies in periodontal disease. Ann R Australas Coll Dent Surg 2000; 15: 57-60.
31. Putt MS, Proskin HM. Custom tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: results of a randomized controlled trial after six months. J Clin Dent 2013; 24(3): 100-7.
32. Polepalle T, Srinivas M, Swamy N, Aluru S, Chakrapani S, Chowdary BA. Local delivery of hyaluronan 0.8% as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol 2015; 19(1): 37-42.
33. Johannsen A, Tellefsen M, Wikesjo U, Johannsen G. Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2009; 80(9): 1493-7.
34. Duarte Fde F, Lotufo RF, Pannuti CM. Local delivery of chlorhexidine gluconate in patients with aggressive periodontitis. J Int Acad Periodontol 2008; 10(1): 31-5.
35. Pappalardo S, Baglio OA, Cappello C, Guarrera S, De Benedittis M, Petruzzi M, et al. Local delivery of antimicrobial drugs in the treatment of chronic adult periodontitis. Minerva Stomatol 2006; 55(11-12): 655-61.
36. Martorelli de Lima AF, Cury CC, Palioto DB, Duro AM, da Silva RC, Wolff LF. Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis. J Clin Periodontol 2004; 31(8): 648-53.
37. Killoy WJ. Chemical treatment of periodontitis: local delivery of antimicrobials. Int Dent J 1998; 48(3 Suppl 1): 305-15.
38. Friesen LR, Williams KB, Krause LS, Killoy WJ. Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis. J Periodontol 2002; 73(1): 13-9.
39. Hayashi K, Takada K, Hirasawa M. Clinical and microbiological effects of controlled-release local delivery of minocycline on periodontitis in dogs. Am J Vet Res 1998; 59(4): 464-7.
40. Lu HK, Chei CJ. Efficacy of subgingivally applied minocycline in the treatment of chronic periodontitis. J Periodontal Res 2005; 40(1): 20-7.
41. Van Dyke TE, Offenbacher S, Braswell L, Lessem J. Enhancing the value of scaling and root-planing: Arestin clinical trial results. J Int Acad Periodontol 2002; 4(3): 72-6.
42. Wennstrom JL, Newman HN, MacNeill SR, Killoy WJ, Griffiths GS, Gillam DG, et al. Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches. J Clin Periodontol 2001; 28(8): 753-61.
43. Soskolne WA, Heasman PA, Stabholz A, Smart GJ, Palmer M, Flashner M, et al. Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. J Periodontol 1997; 68(1): 32-8.
44. Killoy WJ. Local delivery of antimicrobials: a new era in the treatment of adult periodontitis. Compend Contin Educ Dent 1999; 20(4 Suppl): 13-8.
45. Magnusson I. Local delivery of antimicrobial agents for the treatment of periodontitis. Compend Contin Educ Dent 1998;19(10): 953-6.
46. Matesanz-Perez P, Garcia-Gargallo M, Figuero E, Bascones-Martinez A, Sanz M, Herrera D. A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis. J Clin Periodontol 2013; 40(3): 227-41.
47. Graca MA, Watts TL, Wilson RF, Palmer RM. A randomized controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria. J Clin Periodontol 1997; 24(4): 249-53.
48. Bi WR, Jin CX, Xu GT, Yang CQ. Effect of alendronate sodium on the expression of mesenchymal-epithelial transition markers in mice with liver fibrosis. Exp Ther Med 2013; 5(1): 247-52.
49. Lin JH, Duggan DE, Chen IW, Ellsworth RL, inventorsPhysiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals. Drug Metab Dispos 1991; 19(5): 926-32.
50. Russell RG. Bisphosphonates: mode of action and pharmacology. Pediatrics 2007; 119 Suppl 2: S150-62.
51. Reddy MS, Weatherford TW 3rd, Smith CA, West BD, Jeffcoat MK, Jacks TM. Alendronate treatment of naturally-occurring periodontitis in beagle dogs. J Periodontol 1995; 66(3): 211-7.
52. Alakangas A, Selander K, Mulari M, Halleen J, Lehenkari P, Monkkonen J, et al. Alendronate disturbs vesicular trafficking in osteoclasts. Calcif Tissue Int 2002; 70(1): 40-7.
53. Chapple IL, Socransky SS, Dibart S, Glenwright HD, Matthews JB. Chemiluminescent assay of alkaline phosphatase in human gingival crevicular fluid: investigations with an experimental gingivitis model and studies on the source of the enzyme within crevicular fluid. J Clin Periodontol 1996; 23(6): 587-94.
54. Li CY, Zhou YM, Wang L, Li YQ, Fu L, Gong L. Effect of alendronate sodium on torque-out testing on implant-bone interfaces in estrogen-deficient rabbits with alendronate systemic administration]. Hua Xi Kou Qiang Yi Xue Za Zhi 2011; 29(3): 233-6.
55. El-Shinnawi UM, El-Tantawy SI. The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). J Int Acad Periodontol 2003; 5(1): 5-10.
56. Binderman I, Adut M, Yaffe A. Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats. J Periodontol 2000; 71(8): 1236-40.
57. Jenabian N, Haghanifar S, Moghaddamnia A, Hassania N. The Clinical and Radiographic Effects of Sodium Alendronate in Moderate ChronicPeriodontitis. J Mashhad Dental Sch 2010; 33(4): 285-90. [in Persian]
58. Yaffe A, Iztkovich M, Earon Y, Alt I, Lilov R, Binderman I. Local delivery of an amino bisphosphonate prevents the resorptive phase of alveolar bone following mucoperiosteal flap surgery in rats. J Periodontol 1997; 68(9): 884-9.
59. Pradeep AR, Kumari M, Rao NS, Naik SB. 1% alendronate gel as local drug delivery in the treatment of Class II furcation defects: a randomized controlled clinical trial. J Periodontol 2013; 84(3): 307-15.
60. Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial. J Periodontol 2012; 83(1): 19-26.
61. Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel as a local drug delivery system in the treatment of chronic periodontitis: a randomized, controlled clinical trial. J Periodontol 2012; 83(1): 11-8.
62. Lee JK. Bilateral atypical femoral diaphyseal fractures in a patient treated with alendronate sodium. Int J Rheum Dis 2009; 12(2): 149-54.
63. Imai K. Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation. Clin Interv Aging 2013; 8: 681-8.
64. Ezzati Nazhad Dolatabadi J, Hamishehkar H, de la Guardia M, Valizadeh H. A fast and simple spectrofluorometric method for the determination of alendronate sodium in pharmaceuticals. Bioimpacts 2014; 4(1): 39-42.
65. Rhim SY, Park JH, Park YS, Lee MH, Kim DS, Shaw LM, et al. Bioavailability and bioequivalence of two oral formulations of alendronate sodium 70 mg: an open-label, randomized, two-period crossover comparison in healthy Korean adult male volunteers. Clin Ther 2009; 31(5): 1037-45.
66. Finkelman RD, Williams RC. Local delivery of chemotherapeutic agents in periodontal therapy: has its time arrived? J Clin Periodontol 1998; 25(11 Pt 2): 943-6.
67. Veena HR, Prasad D. Evaluation of an aminobisphosphonate (alendronate) in the management of periodontal osseous defects. J Indian Soc Periodontol 2010; 14(1): 40-5.
68. Reddy GT, Kumar TM, Veena. Formulation and evaluation of Alendronate Sodium gel for the treatment of bone resorptive lesions in Periodontitis. Drug Deliv 2005; 12(4): 217-22.
69. Rocha M, Nava LE, Vazquez de la Torre C, Sanchez-Marin F, Garay-Sevilla ME, Malacara JM. Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial. J Periodontol 2001; 72(2): 204-9.
70. Rocha ML, Malacara JM, Sanchez-Marin FJ, Vazquez de la Torre CJ, Fajardo ME. Effect of alendronate on periodontal disease in postmenopausal women: a randomized placebo-controlled trial. J Periodontol 2004; 75(12): 1579-85.
71. Kaynak D, Meffert R, Bostanci H, Gunhan O, Ozkaya OG. A histopathological investigation on the effect of systemic administration of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the rat mandible. J Periodontol 2003; 74(9): 1348-54.
72. Brunsvold MA, Chaves ES, Kornman KS, Aufdemorte TB, Wood R. Effects of a bisphosphonate on experimental periodontitis in monkeys. J Periodontol 1992; 63(10): 825-30.
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Kiany F, Montaseri H, Adibi S, Golshah M, Golshah S. Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study. Feyz. 2017; 21 (1) :42-50
URL: http://feyz.kaums.ac.ir/article-1-3281-fa.html

کیانی فرین، منتصری هاشم، ادیبی صدف، گل شاه مسعود، گل شاه صبا. اثر موضعی آلندرونات سدیم همراه با جرم‌گیری و تسطیح سطح ریشه در مصرف کنندگان سیگار مبتلا به پریودنتیت مزمن: یک مطالعه پایلوت. دوماه نامه علمي ـ پژوهشي فيض. 1396; 21 (1) :42-50

URL: http://feyz.kaums.ac.ir/article-1-3281-fa.html



دوره 21، شماره 1 - ( دوماه نامه 1396 ) برگشت به فهرست نسخه ها
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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