Background: Nanosilver is widely used in medical equipment. This study aimed to evaluate the effects of Silver nanoparticles on WBC and RBC count in male rats.

Materials and Methods: This experimental study was performed on 40 male Wistar rats. The experimental groups were exposed to different concentrations of Silver nanoparticles (50, 100, 200 and 400 ppm). The mean numbers of RBC and WBC count in the mice-treated and control groups at day 12th after the treatment were compared with each other.

Results: Blood damage caused by a single dose of Silver nanoparticles was observed at 50 ppm RBC. According to the results of different studies, the impact will be temporary and will disappear within a month. No significant effects were observed in the other groups.

Conclusion: According to the different studies, the lack of toxicity by nanoparticles, especially in in vivo, can be attributed to their quick removal by the reticuloendothelial system in the liver, spleen and lymph nodes and subsequent disposal of nanoparticles from the body.