Background: Matrix Gla protein chelates calcium ions from subendothelial space of the vessels to the circulation and is known to be a calcium scavenger. Thus, this study aimed to evaluate the association of rs1800801G>A polymorphism, serum MGP and stenosis of coronary artery.

Materials and Methods: One hundred and eighty-two subjects who underwent coronary angiography were recruited. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into the three subgroups: single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD). Genotyping was performed by ARMS-PCR and serum MGP measured by ELISA kit.

Results: The serum MGP and genotype distributions showed no significant difference in the patients compared to the control group (P=0.432 and P=0.079, respectively). In addition, there was no significant difference between rs1800801G>A frequency and gender (P=0.404), and also patient subgroups (P=0.473). AA+AG versus GG showed no association with the severity of the disease.

Conclusion: A (rs1800801) polymorphism within the MGP promoter and serum MGP are not related to the stenosis of coronary artery, and total serum MGP can not be used as a diagnostic factor of coronary stenosis.