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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 647-648 Back to browse issues page
Are there any association between matrix Gla protein (MGP) as a calcium scavenger and coronary artery stenosis?
Abazar Roustazadeh *, Mohammad Najafi, Abdollah Amirfarhangi
Tehran University of Medical Sciences , A-Roustazadeh@razi.tums.ac.ir
Abstract:   (4571 Views)

Background: Matrix Gla protein chelates calcium ions from subendothelial space of the vessels to the circulation and is known to be a calcium scavenger. Thus, this study aimed to evaluate the association of rs1800801G>A polymorphism, serum MGP and stenosis of coronary artery.

Materials and Methods: One hundred and eighty-two subjects who underwent coronary angiography were recruited. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into the three subgroups: single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD). Genotyping was performed by ARMS-PCR and serum MGP measured by ELISA kit.

Results: The serum MGP and genotype distributions showed no significant difference in the patients compared to the control group (P=0.432 and P=0.079, respectively). In addition, there was no significant difference between rs1800801G>A frequency and gender (P=0.404), and also patient subgroups (P=0.473). AA+AG versus GG showed no association with the severity of the disease.

Conclusion: A (rs1800801) polymorphism within the MGP promoter and serum MGP are not related to the stenosis of coronary artery, and total serum MGP can not be used as a diagnostic factor of coronary stenosis.

Keywords: MGP, Coronary artery, Angiography, rs1800801, Stenosis
Full-Text [PDF 92 kb]   (823 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/03/2
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Roustazadeh A, Najafi M, Amirfarhangi A. Are there any association between matrix Gla protein (MGP) as a calcium scavenger and coronary artery stenosis?. Feyz. 2013; 16 (7) :647-648
URL: http://feyz.kaums.ac.ir/article-1-1788-en.html


Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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