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:: Volume 15, Issue 2 (Quarterly 2011) ::
Feyz 2011, 15(2): 105-113 Back to browse issues page
Interaction between apomorphine and histaminergic system of mouse dorsal hippocampus in the elevated plus-maze test of anxiety
Elham Ayazi, Morteza Piri *, Maryam Bananej, Maryam Sadat Shahin, Mohammad Reza Zarrindast
Islamic Azad University, Ardabil Branch , biopiri@iauardabil.ac.ir
Abstract:   (7472 Views)

Background: Histaminergic and dopaminergic systems influence anxiety-related behavior. Furthermore, interaction between histaminergic and dopaminergic receptors has been demonstrated in the modulation of some behaviors in the hippocampus. In the present study, the interaction between histaminergic and dopaminergic receptors of dorsal hippocampus in the anxiety-related behavior has been evaluated.

Materials and Methods: This experimental study was carried out on 140 male NMRI mice. Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride plus xylazine and then placed in a stereotaxic apparatus. Two cannuales were placed in the CA1 region of hippocampus. All animals were allowed to recover for one week before the beginning of the behavioral testing. The elevated plus-maze test was used to evaluate anxiety-related behaviors. One-way analysis of variance (ANOVA) followed by LSD test were done for the statistical analysis of the data. All experiments were conducted in accordance with institutional guidelines for animal care and use.

Results: Intra-CA1 injection of histamine (10 µg/mouse) or apomorphine (0.1 and 0.3 µg/mouse) 5 min before testing induced anxiety. Intra-CA1 injection of apomorphine (0.01 and 0.1 µg/mouse) 2 min before the effective dose of histamine (10 µg/mouse) inhibited the anxiogenic effects of histamine.

Conclusion: It seems that both histaminergic and dopaminergic system not only play a role in the modulation of anxiety in the dorsal hippocampus of mice but also demonstrate a complex interaction as well.

Keywords: Apomorphine, Dorsal hippocampus, Elevated plus-maze, Histamine, Mouse
Full-Text [PDF 235 kb]   (1549 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/06/21
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Ayazi E, Piri M, Bananej M, Shahin M S, Zarrindast M R. Interaction between apomorphine and histaminergic system of mouse dorsal hippocampus in the elevated plus-maze test of anxiety. Feyz. 2011; 15 (2) :105-113
URL: http://feyz.kaums.ac.ir/article-1-1160-en.html


Volume 15, Issue 2 (Quarterly 2011) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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