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:: Volume 23, Issue 4 (Bimonthly 2019) ::
Feyz 2019, 23(4): 361-370 Back to browse issues page
Effect of N-acetyl cysteine supplementation on sperm quality parameters and biochemical markers on the infertile people: A systematic review on clinical trials
Mahsa Shirani , Mehran Nouri * , Gholamreza Askari
Faculty of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. , mehran_nouri71@yahoo.com
Abstract:   (1571 Views)
Background: One of the most important factors in the development of infertility is oxidative damagewhich is mentioned by free radicals. N-acetylcysteine (NAC) is an antioxidant compound that is able to recover free radicals preventing tissue damage as well as protecting the sperm. This study aimed to summarize the data from the clinical trials in relation to the effects of NAC on oxidative stress parameters, sperm count, motility, and morphology of the sperms in the infertile men.
Materials and Methods: By searching in the scientific databases of PubMed, Google Scholar, Science Direct, Scopus, and Web of Science using the N-Acetyl-L-cysteine, NAC, Infertility, Sterility, Sub-fertility keywords, articles released between in 1990-2018 were extracted. Only clinical trials were studied and other types including cross-sectional, prospective, retrospective, overview, etc were excluded. Therefore, the inclusion criteria for this study were considered N-acetylcysteine supplementation.
Result: NAC, as part of glutathione plays a role in restoring reserves and increasing antioxidant activity and due to its sulfidryl group it has the ability to clear free radicals by reacting with reactive oxygen species. On the other hand, increasing the production of active oxygen species due to the imbalance between peroxide and antioxidant substances on the sperm plasma membrane could have a negative effect on sperm performance.
Conclusion: In most studies, the positive effects of NAC supplementation on sperm parameters, antioxidant capacity, and antioxidant enzymes have been proven, but due to the shortage of studies, more trials are needed.
Keywords: Infertility, Fertility, Sperm quality parameters, N-acetylcysteine, NAC
Full-Text [PDF 312 kb]   (434 Downloads)    
Type of Study: Review | Subject: General
Received: 2018/12/9 | Accepted: 2019/06/24 | Published: 2019/09/30
1. Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Hum Reprod 2005; 20(5): 1144-7.
2. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol 2009; 181(2): 741-51.
3. Aflakseir A, Mahdiyar M. The Role of Religious Coping Strategies in Predicting Depression among a Sample of Women with Fertility Problems in Shiraz. J Reprod Infertil 2016; 17(2): 117-22.
4. Parsanezhad ME, Jahromi BN, Zare N, Keramati P, Khalili A, Parsa-Nezhad M. Epidemiology and etiology of infertility in Iran, systematicreview and meta-analysis. Womens Health Issues 2013; 2:6.
5. Mendiola J, Torres-Cantero AM, Vioque J, Moreno-Grau JM, Ten J, Roca M, et al. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil steril 2010; 93(4): 1128-33.
6. Nakae D, Akai H, Kishida H, Kusuoka O, Tsutsumi M, Konishi Y. Age and Organ Dependent Spontaneous Generation of Nuclear 8-Hydroxydeoxyguanosine in Male Fischer 344 Rats. Lab Invest 2000; 80(2): 249-61.
7. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell 2007; 39(1): 44-84.
8. Manna SK, Zhang HJ, Yan T, Oberley LW, Aggarwal BB. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem 1998; 273(21): 13245-54.
9. Irvine DS. Glutathione as a treatment for male infertility. Rev Reprod 1996; 1(1): 6-12.
10. Costabile RA, Spevak M. Cancer and male factor infertility. Oncology (Williston Park) 1998; 12(4): 557-62.
11. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 2004; 25(1-2): 199-210.
12. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997; 10(7): 1535-41.
13. Clement SL, Hellier BC, Elberson LR, Staska RT, Evans MA. Flies (Diptera: Muscidae: Calliphoridae) are efficient pollinators of Allium ampeloprasum L. (Alliaceae) in field cages. J Econ Entomol 2007; 100(1): 131-5.
14. Cobo J, Castiñeira M. Oxidative stress, mitochondrial respiration, and glycemic control: clues from chronic supplementation with Cr3+ or As3+ to male Wistar rats. Nutrition 1997;13(11-12): 965-70.
15. Barekat F, Tavalaee M, Deemeh MR, Bahreinian M, Azadi L, Abbasi H, et al. A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy. Int J Fertil 2016; 10(1): 120-6.
16. Reddy PS, Rani GP, Sainath SB, Meena R, Supriya C. Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice. J Trace Tlem Med Biol 2011; 25(4): 247-53.
17. Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. J Urolo 2009; 74(1): 73-6.
18. Kunle-Alabi OT, Akindele OO, Odoh MI, Oghenetega BO, Raji Y. Comparative effects of coconut water and N-Acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats. Songklanakarin J Sci Technol 2017; 39(6).
19. Feng D, Huang H, Yang Y, Yan T, Jin Y, Cheng X, et al. Ameliorative effects of N-acetylcysteine on fluoride-induced oxidative stress and DNA damage in male rats' testis. Mutation Research 2015; 792: 35-45.
20. da Silva RF, Borges CdS, Villela e Silva P, Missassi G, Kiguti LRA, Pupo AS, et al. The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system. Oxid Med Cell longev 2016; 201(6).
21. Ji YL, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, et al. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian J Androl 2013; 15(2): 290-6.
22. Kumar BA, ReddyAG, Kumar PR, Reddy YR, Rao TM, Haritha C. Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats. J Nat Sci Biol Med 2013; 4(2): 414-9.
23. Anand H, Misro M, Sharma S, Prakash S. Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testis. Andrologia 2015; 47(2): 194-208.
24. Asadpour R, Azari M, Hejazi M, Tayefi H, Zaboli N, editors. Protective effects of garlic aquous extract (Allium sativum), vitamin E, and N-acetylcysteine on reproductive quality of male rats exposed to lead. Vet Res Forum 2013; 4(4): 251-7.
25. Maheshwari A, Misro M, Aggarwal A, Sharma RK. N-acetyl-L-cysteine modulates multiple signaling pathways to rescue male germ cells from apoptosis induced by chronic hCG administration to rats. Apoptosis 2012; 17(6): 551-65.
26. Oksay T, Nazıroğlu M, Ergün O, Doğan S, Özatik O, Armağan A, et al. N‐acetyl cysteine attenuates diazinon exposure‐induced oxidative stress in rat testis. Andrologia 2013; 45(3): 171-7.
27. Duarte F, Blaya R, Telöken PE, Becker D, Fernandes M, Rhoden EL. The effects of N-acetylcysteine on spermatogenesis and degree of testicular germ cell apoptosis in an experimental model of varicocele in rats. Int Urol Nephrol 2010; 42(3): 603-8.
28. Farombi EO, Ugwuezunmba MC, Ezenwadu TT, Oyeyemi MO, Ekor M. Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine. Exp Toxicol Pathol 2008; 60(1): 77-85.
29. Payabvash S, Salmasi AH, Kiumehr S, Tavangar SM, Nourbakhsh B, Faghihi SH, et al. Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. Urol Int 2007; 79(3): 248-54.
30. Çay A, Alver A, Küçük M, Işik O, Eminağaoğlu MS, Karahan SC, et al. The effects of N-acetylcysteine on antioxidant enzymeactivities in experimental testicular torsion. J Surg Res 2006; 131(2): 199-203.
31. Zafarullah M, Li W, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60(1): 6-20.
32. Roberfroid M, Calderon P. Free radicals and oxidation phenomena in biological systems. 1995. New York: Marcel Dekker, Inc.
33. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995; 270(5234): 296-9.
34. Braga PC. Drugs in bronchial mucology: Raven Press (ID); 1989.
35. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2001; 20(2).
36. Clement SL, Hellier BC, Elberson LR, Staska RT, Evans MA. Flies (Diptera: Muscidae: Calliphoridae) are efficient pollinators of Allium ampeloprasum L.(Alliaceae) in field cages. J Economic Entomol 2007; 100(1): 131-5.
37. Sakamoto H, Ogawa Y, Yoshida H. Relationship between testicular volume and varicocele in patients with infertility. J Urol 2008; 71(1): 104-9.
38. Jung A, Schuppe HC. Influence of genital heat stress on semen quality in human. Andrologia 2007; 39(6): 203-15.
39. Cam K, Simsek F, Yuksel M, Turker L, Haklar G, Yalcin S, et al. The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment. Int J Androl 2004; 27(4): 228-33.
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Shirani M, Nouri M, Askari G. Effect of N-acetyl cysteine supplementation on sperm quality parameters and biochemical markers on the infertile people: A systematic review on clinical trials. Feyz. 2019; 23 (4) :361-370
URL: http://feyz.kaums.ac.ir/article-1-3760-en.html

Volume 23, Issue 4 (Bimonthly 2019) Back to browse issues page
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