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Effect of N-acetylcysteine supplementation on sperm quality parameters and biochemical markers of infertile people: A systematic review of clinical trials
Mahsa Shirani , Mehran Nouri * , Gholamreza Askari
Faculty of Nutrition , mehran_nouri71@yahoo.com
Abstract:   (53 Views)
Introduction: According to the WHO definition, infertility is one of the public health problems that is defined as at least an unprotected mixture of non-fertility. One of the most important factors in the development of infertility is oxidative damage to testicular cells, which are mentioned by free radicals. N-acetylcysteine ​​(NAC) is an antioxidant compound that is able to recover free radicals, thus preventing tissue damage as well as protecting the sperm. The purpose of this study was to summarize the data from clinical trials in relation to the effects of NAC on oxidative stress parameters, morphology, movement, number and frequency of DNA in infertile men.
Method: By searching in the scientific databases of PubMed, Google Scholar, Science Direct, Scopus and Web of Science using the N-Acetyl-L-cysteine, N-Acetylcysteine, NAC, Infertility, Sterility, Sub-fertility, fertility keywords Released between 1990 and 2018. Of the various types of studies, only clinical trials were studied and other types, including cross-sectional, prospective, retrospective, overview, etc. were excluded. The inclusion criteria for N-acetylcysteine supplementation were therefore considered.
Findings: NAC is a derivative of the amino acid L-cysteine and can act as glutathione precursor to restore its reserves and increase antioxidant activity, and since the source of sulfidryl group in cells is the ability to clear free radicals by reacting with Active oxygen species, such as hydroxyl radicals. On the other hand, increasing the production of reactive oxygen species by the imbalance between prooxidant and antioxidant substances on the sperm plasma membrane has a toxic effect and therefore can have a detrimental effect on sperm production.
Conclusion: In most studies, the positive effects of NAC supplementation on sperm parameters, antioxidant capacity and antioxidant enzymes have been proven, but due to the lack of studies, more trials are needed in this field, especially on humans.
Keywords: Infertility, fertility, N-Acetylcysteine, NAC
Type of Study: Review | Subject: General
Received: 2018/12/9 | Accepted: 2019/06/24
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