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:: Volume 16, Issue 5 (Bimonthly 2012) ::
Feyz 2012, 16(5): 426-432 Back to browse issues page
Comparing the antimicrobial properties of pomegranate seed and peel extract with common antibiotics used on helicobacter pylori isolated from biopsies of patients referring to Kashan Shahid-Beheshti hospital
Hamed Saffari , Mahmood Saffari , Abbas Arj , Abdolrasool Haghir-Ebrahim-Abadi
Kashan University of Medical Sciences , hamed_saffary@yahoo.com
Abstract:   (15000 Views)

Background: Helicobacter pylori (H. pylori) infection is a worldwide problem nowadays. Considering H. pylori resistance to antibiotics, the need for complementary therapies or substances that reduce antibiotic resistance is completely obvious. The purpose of this study was to investigate the antimicrobial properties of pomegranate seed and peel extract against H. pylori.

Materials and Methods: Pomegranate seed and peel extract were prepared in different concentrations (10, 15 and 20 percent) separately using the DMSO. Mixtures of these concentrates with meteronidazol and claritromycin (each with 3 concentrates) as well as the discs for each concentrate were prepared. Finally, H. pylori resistance in stomach biopsies of candidates for esophagoscopy was evaluated for each disc during 2008-2009 in Kashan.

Results: Considering an inhibitory zones around each disc and comparing those to the tables of national committee for clinical laboratory standards (NCCLS), antibiotic sensitivity to clarithromycin and meteronidazol increased significantly with pomegranate peel extract and it was not significantly increased with the pomegranate seed extract compared to the antibiotic discs alone.

Conclusion: Although the pomegranate seed and peel extract has no effect on inhibition zone of H. pylori, it can be used in reducing antibiotic resistance of meteronidazol and clarithromycin to eradicate H. pylori.

Keywords: Pomegranate extract, Antibiotic resistance, Helicobacter pylori, Antimicrobial effects, Meteronidazol, Clarithromycin
Full-Text [PDF 202 kb]   (16567 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2012/10/15 | Revised: 2012/10/28 | Published: 2012/10/15
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Saffari H, Saffari M, Arj A, Haghir-Ebrahim-Abadi A. Comparing the antimicrobial properties of pomegranate seed and peel extract with common antibiotics used on helicobacter pylori isolated from biopsies of patients referring to Kashan Shahid-Beheshti hospital. Feyz 2012; 16 (5) :426-432
URL: http://feyz.kaums.ac.ir/article-1-1634-en.html


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This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
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Volume 16, Issue 5 (Bimonthly 2012) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
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