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:: Volume 13, Issue 4 (Quaterly 2010) ::
Feyz 2010, 13(4): 278-284 Back to browse issues page
Evaluating the efficacy of anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis disease
Batol Zamani *, Kamal Esalatmanesh, Alireza Fakhrzad, Hasan Ehteram, Sayyed Gholam Abas Mousavi, Mohsen Arbabi
, zamani-b@kaums.ac.ir
Abstract:   (6856 Views)

Background: Rheumatoid arthritis is one of the most common autoimmune diseases. Early diagnosis can prevent side effects and disability. Anti-cyclic citrullinated peptide antibody is a specific marker to diagnose rheumatoid arthritis. This study was carried out to evaluate the efficacy of anti-cyclic citrullinated peptide in comparison with rheumatoid factor in rheumatoid arthritis patients referred to Behshti Hospital of Kashan city during 2006-7.

Materials and Methods: This diagnostic value study was done on 98 randomly selected rheumatoid arthritis patients and 75 patients with other rheumatic diseases. In this study rheumatoid factor titer>35 IU/ml and anti-cyclic citrullinated peptide>6.25 IU/ml were considered positive.

Results: Anti-cyclic citrullinated peptide compared to rheumatoid factor had a higher sensitivity (73.5% vs. 69.4%), specificity (88% vs. 84%), positive predictive value (88.9% vs. 85%), and negative predictive value (71.7% vs. 67.7%) for rheumatoid arthritis. The use of rheumatoid factor and anti-cyclic citrullinated peptide test together increased the specificity and positive predictive value for diagnosis of rheumatoid arthritis to 93.3% and 92.4%, respectively. The mean anti-cyclic citrullinated peptide showed a significant difference in Rheumatoid arthritis (46.8 IU/ml( in comparison to non rheumatoid arthritis patients (5.3 IU/ml).

Conclusion: Anti-cyclic citrullinated peptide had a better diagnostic value when compared to rheumatoid factor for detection of rheumatoid arthritis. Also combined use of rheumatoid factor and anti-cyclic citrullinated peptide had a higher specificity and positive predictive value than each alone for the diagnosis of rheumatoid arthritis.

Keywords: Rheumatoid arthritis, Rheumatoid factor, Anti-cyclic citrullinated peptide, Sensitivity and specificity, Predictive value of tests
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Type of Study: Research | Subject: General
Received: 2010/02/1
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Zamani B, Esalatmanesh K, Fakhrzad A, Ehteram H, Mousavi S G A, Arbabi M. Evaluating the efficacy of anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis disease. Feyz. 2010; 13 (4) :278-284
URL: http://feyz.kaums.ac.ir/article-1-826-en.html


Volume 13, Issue 4 (Quaterly 2010) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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