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:: Volume 10, Issue 4 (Quarterly 2007) ::
Feyz 2007, 10(4): 14-18 Back to browse issues page
Preventive effect of shoseiryuto on oleic acid induced hypoxemia in guinea pigs
Saeid Golbidi *, Sayed Ali Reza Ebadi, Azam Mesdaghinia
, golbidi_s@kaums.ac.ir
Abstract:   (6588 Views)

Background: Acute respiratory distress syndrome (ARDS) is a severe and complicated lung inflammation. Intravenous injection of oleic acid has been accepted as a laboratory model for this disease. Shoseiryuto is a herbad compound, which is used for the treatment of several inflammatory diseases including asthma. The aim of this study was to evaluate the possible preventive effect of shoseiryuto on oleic acid-induced hypoxemia.

Materials and methods: Suspension of shoseiryuto powder in water was used acutely (intraperitoneal injection) and chronically (oral) in four groups of guinea pigs (n=8). The animals were anesthetized by pentobarbital and after cataterization of axillary arteries and vein the possible preventive effect of shoseiryuto on oleic acid induced hypoxemia was evaluated.

Results: Intravenous injection of oleic acid caused a significant decrease in PaO2, 6 and 10 minutes after injection (P<0.05). Acute and chronic administration of shoseiryuto powder showed a significant preventive effect on oleic acid induced hypoxemia (P<0.05).

Conclusion: Shoseiryuto showed a significant effect in prevention of oleic acid induced hypoxemia. Based on the various properties of this herb, several different mechanisms can be proposed.

Keywords: Acute respiratory distress syndrome, Oleic acid, Hypoxemia, Kampo medicine, Shoseiryuto
Full-Text [PDF 196 kb]   (1480 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/10/27
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Golbidi S, Ebadi S A R, Mesdaghinia A. Preventive effect of shoseiryuto on oleic acid induced hypoxemia in guinea pigs. Feyz. 2007; 10 (4) :14-18
URL: http://feyz.kaums.ac.ir/article-1-68-en.html


Volume 10, Issue 4 (Quarterly 2007) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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