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:: Volume 10, Issue 4 (Quarterly 2007) ::
Feyz 2007, 10(4): 8-13 Back to browse issues page
Effect of garlic extract on gastric acid and pepsin secretion in rat
Mehrdad Shahrani *, Mahmoud Rafieian, Heayatolah Shirzad, Morteza Hashemzadeh, Hossein Yoosefi, Reza Khadivi, Sayed Asadolah Amini, Mohammad taghi Moradi, Jafar Mogadasi, Mohammad Reza Rahmani
Abstract:   (8066 Views)

Background : Garlic (Allium sativum) is widely used as an additive in pickles around the world and particularly in Iran. Considering Garlic treatment function this study was conducted to survey the effect of this plant entrant on the secretion rate of acid and pepsin in the stomach.

Materials and Methods: This study involves two groups of 12 rats (Control group and Garlic group). Animals were gone under anesthesia by nesdonal with 50 mg/kg IP and undertook surgical process, tracheotomy, laparatomy and gasteroadeodenostomy. Garlic extract 100 mg/kg was administered by gasterodeodenostomy canola. Tnyostric secretions, obtained in wash out way, 15 and 30 minutes after stress acid and pepsin were measured by Tetrameter and Anson aprooch, respectively.

Results: The amount of acid in both bases was significantly increased in the garlic group compared to the control group (p<0.001). not significantly change was observed in pepsin secretion. The elevation of acid secretion had no significant relevance with sex.

Conclusion: Garlic (Allium sativum) increases acid secretion when used in food regimen.
Keywords: Garlic extract, Gastric acid, Secretion pepsin, Rat
Full-Text [PDF 155 kb]   (1962 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/10/27
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Shahrani M, Rafieian M, Shirzad H, Hashemzadeh M, Yoosefi H, Khadivi R, et al . Effect of garlic extract on gastric acid and pepsin secretion in rat. Feyz. 2007; 10 (4) :8-13
URL: http://feyz.kaums.ac.ir/article-1-67-en.html


Volume 10, Issue 4 (Quarterly 2007) Back to browse issues page
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