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The effect of HIIT on cardiac inflammatory markers in mice fed a Western diet
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Mostafa Akram Ahmad Al-Karawi    , Elahe Malekyian fini * , Musa Khalafi |
| Kashan University , malekyian.e@kashanu.ac.ir |
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Abstract: (1 Views) |
Background: A high-fat and high-carbohydrate diet increases inflammatory cytokines such as TNF-α and IL-1β, leading to activation of the NF-κB gene in cardiac tissue. This activation contributes to inflammation, tissue damage, and the development of cardiovascular diseases. The present study aimed to investigate the effect of high-intensity interval training on inflammatory markers TNF-α, NF-κB, and IL-1β in the heart tissue of rats fed a high-fat, high-carbohydrate diet.
Materials and Methods: Eighteen rats were randomly divided into three groups: Control (CON) with a standard diet, Western Diet (WD), and Western Diet plus HIIT (WD+HIIT). The Western diet consisted of 20% protein, 35% carbohydrate, and 45% fat. The HIIT protocol involved 10 bouts of 2-minute running intervals at 85–90% of maximal speed, interspersed with 2-minute active rest periods at 50% of maximal speed, performed three sessions per week for four weeks on a treadmill with a 5° incline.
Results: In the WD group, the levels of TNF-α, NFκB, and IL-1β markers were significantly increased compared to the CON group (P<0.05). High-intensity interval training caused a decrease in all three inflammatory markers in the WD+HIIT group (P<0.05), and a significant decrease was observed in the levels of NFκB and IL-1B in the WD+HIIT group (P<0.05).
Conclusion: High-intensity interval training markedly reduced inflammatory markers in rats subjected to a high-fat and high-carbohydrate diet. Given its significant anti-inflammatory effects, HIIT can be considered a promising non-pharmacological approach for mitigating diet-induced cardiac inflammation. |
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| Keywords: High-intensity interval training, High-fat high-carbohydrate diet, Inflammatory cytokines, TNF-α, IL-1β |
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Type of Study: Research |
Subject:
General
Received: 2026/02/18 | Revised: 2026/07/1 | Accepted: 2026/07/1 | Published: 2026/07/1
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