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The effect assessment of zinc oxide (ZnO) nanoparticles against gram-positive and gram-negative pathogenic bacteria
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Maryam Jamalan    , Fatemeh Ghaffarian Sayeli , Amin Moradihasanabad , Maryam Akbary , Ali Sobhaninasab * |
| , ali.sobhaninasab@gmail.com |
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Abstract: (6 Views) |
Background: The antimicrobial properties of metal oxide nanoparticles are a notable feature in nanotechnology to combat pathogens resistant to antibacterial agents. This study aimed to synthesize zinc oxide (ZnO) nanoparticles, determine the properties of the synthesized nanoparticles, and assess their antimicrobial effects.
Materials and Methods: The synthesis of ZnO nanoparticles was carried out using the co-precipitation method, and the characteristics of the synthesized nanoparticles were determined using SEM, XRD, and FTIR analysis. The antimicrobial properties of the synthesized nanoparticles were determined by the determination of MBC and MIC of the nanoparticles using the broth microdilution method.
Results: The SEM image of the ZnO nanoparticles showed the shape of small clusters of spherical particles, and the size of the particles was nanometric (70-200 nm). Sharp peaks in XRD analysis indicated purity and proper crystallization of the nanoparticles, and FTIR spectra with a peak at 811.1 indicated the synthesis of these nanoparticles. The MIC and MBC levels for the Gram-positive and Gram-negative bacteria studied in this study were determined to be 0.15625-1.25 mg/ml and 0.3125-2.5 mg/ml, respectively.
Conclusion: The zinc oxide nanoparticles synthesized in this study show suitable nano-structure, size, and antimicrobial properties and are recommended for use as an antibacterial compound for various applications.
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| Keywords: Nanotechnology, Bacterial Resistance, Bacterial pathogens, Zinc Oxide |
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2025/12/30 | Revised: 2026/05/19 | Accepted: 2026/05/19
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