History and Objectives: Due to the role of aluminum on inhibition of calcium channels and use of preparations containing aluminum as anti acid and in order to determine the effect of the veinal injection of aluminum (Systemic) on secretion of gastric acid due to distension, the present study was conducted on anesthetized rats.

Materials and Methods: An experimental study on anesthetized tracheostomized rats was undertaken. 1.5ml/100g distension was created. In control group (10 rats) and control groups (8 rats in each group) physiological saline solution placed in gastric cavity. Aluminum chloride (25, 50, 100, 200 ?g aluminum/kg body weight) and saline solution (0.5ml total volume) was injected to experimental and control groups respectively. At 15 minutes intervals, gastric acid content was measured by titration.

Results: Significant acid secretion in control group compared to the basal level was absorbed (P<0.001) while distension did not culminate acid secretion in any significant extent.

Conclusion: It seems that preparations containing aluminum not only creat buffer effect in gastric cavity (As an antacid) but also it inhibits gastric acid secretion in systematic manner.