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The effect of dexmedetomidine on the oxidative stress status of kidney tissue following chronic restraint stress in male mice
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Tahereh Ebrahimi Masouleh    , Jafar Rahmani Kahnamooei * , Mohammadreza Nasirzadeh |
| Tabriz medical sciences, Islamic Azad University, Tabriz, Iran. , rahmani@iau.ir |
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Abstract: (3 Views) |
Introduction: Anxiety and depression are important and significant diseases in today's societies. Chronic inhibitory stress disrupts the oxidant-antioxidant balance. This study investigates the protective effects of Dexmedetomidine (Dex) against oxidative stress induced by chronic inhibitory stress in rat kidney.
Materials and Methods: In this study, 40 mice were divided into 5 groups (n=8): 1) Control, 2) Normal Saline (NS)-Stress, 3) Dex20-Stress, 4) Dex 40-Stress, and 5) Dex 80-Stress. The mice experienced a chronic inhibitory stress model for 21 days for 3 hours daily. In the Dex groups, animals received the drug at doses of 20, 40, and 80 µg/kg during the stress induction period. Finally, serum levels of corticosterone, urea, creatinine, and kidney tissue antioxidant enzymes were measured.
Results: It was shown that chronic inhibitory stress caused a significant increase in serum levels of corticosterone, urea, and creatinine compared to the control group (p < 0.05). Stress, also significantly increased the level of lipid peroxidation index and reduced the activity of antioxidant enzymes SOD and GPX. The administration of dexmedetomidine was able to adjust the levels of corticosterone and antioxidant enzymes SOD and GPX to the control level (p < 0.05).
Discussion and Conclusion: The results showed that dexmedetomidine has antioxidant properties and is able to prevent changes in serum urea, creatinine, and corticosterone, as well as MDA levels and antioxidant enzymes SOD and GPX in mouse kidney tissue against chronic inhibitory stress.
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| Keywords: Chronic inhibitory stress, oxidative stress, kidney tissue, Dexmedetomidine, mice. |
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Type of Study: Research |
Subject:
medicine, paraclinic
Received: 2025/07/27 | Revised: 2026/09/20 | Accepted: 2026/09/20
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