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The Effect of a Course of HIIT Swimming Exercises on Liver Tissue Leptin and Hepassacin Proteins in Rats with NASH Induced by High-Fat Diet
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Seyed Mohammad Nabi Bahrani    , Saleh Rahmati * , Vahid Moghaddam |
| Associate Professor, Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran. , Rahmatisalehrahmati@pardisiau.ac.ir |
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Abstract: (13 Views) |
Background: HIIT exercises are among the effective methods in the non-drug treatment of NASH. However, there is a difference of opinion on the best exercise protocol in this field. As a result, the aim of the current research was to investigate HIIT swimming exercise from a cellular-molecular point of view in the treatment of NASH. Materials and Methods: In this experimental study, 40 male Sprague-Dawley rats (age: eight weeks, weight: 230±20 grams) were selected. After proving non-alcoholic steatohepatitis, the rats were divided into four groups: healthy-without exercise (N=9), healthy-exercise (N=9), patient-without exercise (N=9) and patient-exercise (N=9). ) were divided. The HIIT swimming training protocol (eight weeks, three days a week, even days) consisted of 20 30-second swimming bouts with 30-second rest between each bout. The load applied in the interval training in the first week was seven percent of the body weight of each rat and one percent was added every week. So, in the eighth week, they swam with 14% of their body weight. Leptin and HPS proteins in liver tissue were measured by Western blotting. One-way variance was used to determine the difference between groups, and Bonferroni's post hoc test was used to determine the difference between groups. All statistical analyzes were done using SPSS26 software and the significance level (P<0.05) was determined. Results: Leptin protein levels were significantly higher in the healthy-exercised group compared to the patient-without exercise group (P=0.031).There was a significant increase in HPS protein level in the patient-without-exercise group compared to healthy-without-exercise (P=0.013) and healthy-exercise (P=0.01). Also, there was a non-significant decrease of this protein in the patient-training group compared to the patient-without training (P=0.15). Conclusions: despite the constant consumption of high-fat diet, this exercise model showed good results, however, more research is needed in this field to obtain definitive results.
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| Keywords: Non-Alcoholic SteatoHepatitis, NASH, Adiponectin, Hepasaicin, Exercise |
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Type of Study: Research |
Subject:
General
Received: 2024/12/5 | Revised: 2025/07/8 | Accepted: 2025/07/7
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