Introduction: Effective airway control is a cornerstone of safety in general anesthesia, and the choice of method significantly impacts surgical success, complications, and patient recovery. This study aimed to compare hemodynamic indices and complications between endotracheal intubation (ETT) and laryngeal mask airway (LMA) in patients undergoing lumbar disc surgery. Methods: This clinical trial study was conducted on 80 patients undergoing lumbar disc surgery at Shahid Beheshti Hospital in Kashan in 2022. Patients were selected using convenience sampling and randomly allocated into two groups of 40: endotracheal tube and laryngeal mask airway. Airway management with a laryngeal mask was performed in the prone position, and with an endotracheal tube in the supine position. Hemodynamic changes were compared between the two groups before the intervention and at 5, 10, 15, 30, 45, and 60 minutes post-intervention, as well as during the recovery phase. Data were analyzed using SPSS software version 22 and descriptive and inferential statistical tests (independent t-test, ANCOVA, repeated measures ANOVA, and Fisher’s exact test). Findings: The results indicated no significant difference in age and gender between the two groups (P < 0.05). There were no significant differences in any of the variables before the intervention in the two groups (P < 0.050). However, heart rate from 5 minutes to 60 minutes post-intervention and maximal inspiratory pressure from 5 minutes to 45 minutes post-intervention were significantly higher in the standard endotracheal tube group compared to the laryngeal mask airway group (P < 0.05). Mean arterial pressure was higher in the standard endotracheal tube group at 5 minutes post-intervention (P = 0.018) and in the laryngeal mask airway group at 45 minutes post-intervention (P = 0.022). There was no significant difference in arterial oxygen saturation between the two groups at any of the measured time points (P < 0.05). End-tidal carbon dioxide pressure was significantly higher only in the laryngeal mask airway group at 45 minutes post-intervention (P = 0.011). The hemodynamic index showed significant differences over time in both the laryngeal mask airway and endotracheal tube groups (P < 0.05). Conclusion:The results of this study show that the use of a laryngeal mask airway in lumbar disc surgery is associated with greater hemodynamic stability and reduced gastrointestinal complications compared to endotracheal intubation. This method may be considered by anesthesiologists as a safe and effective alternative, especially in patients who need to maintain physiological stability.