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THE EFFECT OF A COMBINED TRAINING COURSE WITH N-ACETYLCYSTEINE SUPPLEMENTATION ON INFLAMMATORY LEVELS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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Amirreza Ebrahimi    , Shadmehr Mirdar2 * |
| Mazandaran University, Iran , mirdarshadmehr@gmail.com |
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Abstract: (49 Views) |
Background: Chronic obstructive pulmonary disease (COPD) is one of the respiratory diseases in which inflammation plays an important role in its development. Exercises and nutritional strategies are effective in improving inflammation; Therefore, the aim of the present study is the effect of a combined training course with N-acetylcysteine supplementation on the inflammatory levels of patients with chronic obstructive pulmonary disease.
Materials & Methods: In this semi-experimental study, 80 men with COPD were randomly assigned to 4 combined exercise groups, combined exercise group with supplement consumption, supplement group, and placebo group equally (20 people). The exercises were performed for 12 weeks and three sessions per week for 60 minutes. 1800 mg of N-acetylcysteine supplement was prescribed daily along with three main meals. Data were analyzed with SPSS27 software and ANOVA test at a significance level of 0.05.
Results: In the supplement+exercise group, a greater decrease in the values of interleukin-6 (12.90%), interleukin-8 (22.30%) and CRP (5%) was observed compared to the pre-test. By performing the ANCOVA test, it was observed that there is a significant difference between the groups in the indices of interleukin-6 (p=0.03), interleukin-8 (p=0.011), and CRP (p=0.04)..
Conclusion: The results of our study show that combined exercises with N-acetylcysteine supplementation have a significant improvement in interleukin-6, interleukin-8 and CRP indices in COPD patients
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| Keywords: combined exercises, N-acetylcysteine, chronic pulmonary obstruction, interleukin-6, interleukin-8, C-reactive protein |
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Type of Study: Research |
Subject:
General
Received: 2024/08/31 | Revised: 2024/11/12 | Accepted: 2024/11/12
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