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:: Volume 28, Issue 5 (Bimonthly 2024) ::
Feyz Med Sci J 2024, 28(5): 500-510 Back to browse issues page
Effect of combined exercise and N-acetylcysteine supplementation on inflammatory markers in patients with chronic obstructive pulmonary disease
Amirreza Ebrahimi , Shadmehr Mirdar *
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran & Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran , mirdarshadmehr@gmail.com
Abstract:   (598 Views)
Background and Aim: Chronic obstructive pulmonary disease (COPD) is a respiratory disease in which inflammation plays a significant role in its progression. Exercise and nutritional strategies are effective in improving inflammation; therefore, the aim of this study was to determine the effect of a combined exercise program and N-acetylcysteine supplementation on inflammatory markers in patients with COPD.
Methods: In this semi-experimental study, 80 male patients with COPD were randomly divided into 4 groups (20 subjects each): combined exercise, combined exercise with supplementation, supplementation, and placebo. The exercises were performed for 12 weeks, 6 sessions per week, for 60 minutes. 1800 mg of N-acetylcysteine supplement was administered daily along with 3 main meals. The levels of interleukin-6, interleukin-8, and C-reactive protein were measured in the blood at pre- and post-test.
Results: After 12 weeks of intervention, the mean values of interleukin-6, interleukin-8, and CRP decreased significantly by 12.9%, 20.3%, and 5%, respectively, in the exercise + supplement group (P=0.001). Interleukin-6 (P=0.001), interleukin-8 (P=0.001), and CRP (P=0.04) levels were significantly lower in the exercise + supplement group compared to the placebo group. Moreover, interleukin-6 (P=0.001) and interleukin-8 (P=0.001) levels were significantly lower in the exercise group compared to the placebo group.
Conclusion: It seems that combined exercise and N-acetylcysteine supplementation have a positive effect on interleukin-6, interleukin-8, and CRP markers in patients with COPD.
Keywords: Combined exercise, N-acetylcysteine, Chronic obstructive pulmonary disease, Interleukin-6
Full-Text [PDF 480 kb]   (374 Downloads)    
Type of Study: Research | Subject: General
Received: 2024/08/31 | Revised: 2025/03/10 | Accepted: 2024/11/12 | Published: 2024/12/23
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Ebrahimi A, Mirdar S. Effect of combined exercise and N-acetylcysteine supplementation on inflammatory markers in patients with chronic obstructive pulmonary disease. Feyz Med Sci J 2024; 28 (5) :500-510
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Volume 28, Issue 5 (Bimonthly 2024) Back to browse issues page
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