1. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010; 6 (11): 625-35. doi:10.1038/nrrheum.2010.159 PMid:20924410

2. Skou ST, Pedersen BK, Abbott JH, Patterson B, Barton C. Physical Activity and Exercise Therapy Benefit More Than Just Symptoms and Impairments in People With Hip and Knee Osteoarthritis. J Orthop Sports Phys Ther. 2018; 48 (6): 439-47. doi:10.2519/jospt.2018.7877 PMid:29669488

3. Wang R, Tian H, Guo D, Tian Q, Yao T, Kong X. Impacts of exercise intervention on various diseases in rats. J Sport Health Sci. 2020; 9(3): 211-27. doi:10.1016/j.jshs.2019.09.008 PMid:32444146 PMCid:PMC7242221

4. Schulz JM, Birmingham TB, Atkinson HF, Woehrle E, Primeau CA, Lukacs MJ, et al. Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis. Br J Sports Med. 2020; 54 (13): 771-5. doi:10.1136/bjsports-2018-100231 PMid:31848152

5. Bricca A, Juhl CB, Grodzinsky AJ, Roos EM. Impact of a daily exercise dose on knee joint cartilage - a systematic review and meta-analysis of randomized controlled trials in healthy animals. Osteoarthritis Cartilage. 2017; 25 (8): 1223-37. doi:10.1016/j.joca.2017.03.009 PMid:28323138

6. Kabiri S, Halabchi F, Angoorani H, Yekaninejad S. Comparison of three modes of aerobic exercise combined with resistance training on the pain and function of patients with knee osteoarthritis: A randomized controlled trial. Phys Ther Sport. 2018; 32 22-28. doi:10.1016/j.ptsp.2018.04.001 PMid:29677565

7. Loew L, Brosseau L, Kenny GP, Durand-Bush N, Poitras S, De Angelis G, et al. An evidence-based walking program among older people with knee osteoarthritis: the PEP (participant exercise preference) pilot randomized controlled trial. Clin Rheumatol. 2017; 36 (7): 1607-16. doi:10.1007/s10067-017-3606-9 PMid:28332010

8. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science (New York, NY). 1999; 284 (5411): 143-7. doi:10.1126/science.284.5411.143 PMid:10102814

9. Badyra B, Sułkowski M, Milczarek O, Majka M. Mesenchymal stem cells as a multimodal treatment for nervous system diseases. Stem Cells Translational Med. 2020; 9 (10): 1174-89. doi:10.1002/sctm.19-0430 PMid:32573961 PMCid:PMC7519763

10. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. Int Society Cellular Therapy position statement. Cytotherapy. 2006; 8(4): 315-7. doi:10.1080/14653240600855905PMid:16923606

11. Vonk LA, van Dooremalen SFJ, Liv N, Klumperman J, Coffer PJ, Saris DBF, et al. Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro. Theranostics. 2018; 8 (4): 906-20. doi:10.7150/thno.20746 PMid:29463990 PMCid:PMC5817101

12. Zhang W, Robertson WB, Zhao J, Chen W, Xu J Emerging Trend in the Pharmacotherapy of Osteoarthritis. Front Endocrinol. 2019; 10 431. doi:10.3389/fendo.2019.00431 PMid:31312184 PMCid:PMC6614338

13. Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood. 2005; 105 (5): 2214-19. doi:10.1182/blood-2004-07-2921 PMid:15514012

14. Zhang X, Yang Y, Li X, Zhang H, Gang Y, Bai L. Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model. Int J Mol Med. 2019; 43 (1): 336-44. doi:10.3892/ijmm.2018.3948

15. Lampropoulou-Adamidou K, Lelovas P, Karadimas EV, Liakou C, Triantafillopoulos IK, Dontas I, et al. Useful animal models for the research of osteoarthritis. Eur J Orthop Surg Traumatol. 2014; 24 (3): 263-71. doi:10.1007/s00590-013-1205-2 PMid:23508348

16. Bendele AM. Animal models of osteoarthritis. J Musculoskelet Neuronal Int. 2001; 1 (4): 363-76.

17. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res. 2016; 11 19. doi:10.1186/s13018-016-0346-5 PMid:26837951 PMCid:PMC4738796

18. Ghanbari-Niaki A, Rahmati-Ahmadabad S, Ansari-Pirsaraei ZJI Effects of aerobic training on tissue nesfatin-1/nucleobindin-2 mrna, plasma nesfatin-1 and high-density lipoprotein concentration in female rats. IJHPA. 2013; 4(2):1-7

19. Kim JE, Lee SM, Kim SH, Tatman P, Gee AO, Kim DH, Lee KE, Jung Y, Kim SJ Effect of self-assembled peptide-mesenchymal stem cell complex on the progression of osteoarthritis in a rat model. Int J Nanomedicine. 2014; 9 Suppl 1 (Suppl 1): 141-57. doi:10.2147/IJN.S54114 PMid:24872709 PMCid:PMC4024982

20. Shirvani H, Ghanbari-Niaki A, Rahmati-Ahmadabad S, Sobhani V. Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression. Int J Appl Exercise Physiol. 2017; 6 (1): 72-85. doi:10.22631/ijaep.v6i1.118

21. Ye Y, Zhou J. The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway. Front Endocrinol (Lausanne). 2023:14:1117489. doi:10.3389/fendo.2023.1117489 PMid:36998478 PMCid:PMC10043491

22. Wang X, Wang D, Deng B, Yan L Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023; 118 109982. doi:10.1016/j.intimp.2023.109982 PMid:36989902

23. Liu HW, Chang SJ. Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice. Front Physiol. 2018; 9 636. doi:10.3389/fphys.2018.00636 PMid:29896118 PMCid:PMC5987703

24. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018; 9 (24): 17181-98. doi:10.18632/oncotarget.24729 PMid:29682215 PMCid:PMC5908316

25. Kong H, Wang XQ, Zhang XA. Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism. Front Aging Neurosci. 2022; 14 854026. doi:10.3389/fnagi.2022.854026 PMid:35592699 PMCid:PMC9110817

26. Nedunchezhiyan U, Varughese I, Sun AR, Wu X, Crawford R, Prasadam I. Obesity, Inflammation, and Immune System in Osteoarthritis. Front Immunol. 2022; 13 907750. doi:10.3389/fimmu.2022.907750 PMid:35860250 PMCid:PMC9289681

27. Man GS, Mologhianu G Osteoarthritis pathogenesis - a complex process that involves the entire joint. J Med Life. 2014; 7 (1): 37-41.

28. Pedersen BK, Saltin B Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015; 25 Suppl 3 1-72. doi:10.1111/sms.12581 PMid:26606383

29. Hulejová H, Baresová V, Klézl Z, Polanská M, Adam M, Senolt L. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine. 2007; 38 (3): 151-156. doi:10.1016/j.cyto.2007.06.001 PMid:17689092

30. Ullah I, Subbarao RB, Rho GJ Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015; 35 (2): doi:10.1042/BSR20150025 PMid:25797907 PMCid:PMC4413017

31. Mostafa A, Korayem HE, Fekry E, Hosny S The Effect of Intra-articular versus Intravenous Injection of Mesenchymal Stem Cells on Experimentally-Induced Knee Joint Osteoarthritis. J Microsc ultrastruct. 2021; 9 (1): 31-38. doi:10.4103/JMAU.JMAU_2_20 PMid:33850710 PMCid:PMC8030543

32. Carneiro DD, Araújo LT, Santos GC, Damasceno PKF, Vieira JL, Santos RRD, et al. Clinical Trials with Mesenchymal Stem Cell Therapies for Osteoarthritis: Challenges in the Regeneration of Articular Cartilage. Int J Mol Sci. 2023; 24 (12): doi:10.3390/ijms24129939 PMid:37373096 PMCid:PMC10298392