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:: Volume 28, Issue 4 (Bimothly 2024) ::
Feyz Med Sci J 2024, 28(4): 392-399 Back to browse issues page
Growth response to magnesium supplementation in pregnant women at risk of intrauterine growth restriction (IUGR)
Elaheh Mesdaghinia , Parastoo Hedayati * , Nafiseh Soheilipour , Hamid Reza Gilasi , Mohadeseh Zarei Yazdeli
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran , moraveji524@gmail.com
Abstract:   (246 Views)
Background and Aim: Given the significance of intrauterine growth restriction (IUGR) and the unclear mechanisms by which magnesium may prevent it, this study aimed to evaluate the growth response to magnesium supplementation in pregnant women at risk of IUGR in Kashan, Iran.
Methods: This double-blind randomized clinical trial involved 70 women identified as being at risk for IUGR through uterine artery Doppler ultrasound. Women between 16 and 30 weeks of gestation were randomly assigned to two groups: one receiving a daily supplement of 250 mg of magnesium (n=35) and the other receiving a placebo (n=35) for a duration of 14 weeks. At the end of the study, biomarkers of oxidative stress (MDA, TAC, and GSH), lipid profile (total cholesterol, LDL-C, HDL-C, and triglycerides), insulin function parameters, inflammatory factors (hs-CRP and nitric oxide), and growth responses were assessed.
Results: Daily magnesium supplementation for 14 weeks positively influenced the uterine artery resistance index in women at risk of IUGR. Following the intervention, magnesium supplementation resulted in a significant decrease in serum insulin levels and insulin resistance, alongside a notable increase in insulin sensitivity compared to the placebo group; however, there was no effect on fasting blood sugar levels. The serum levels of triglycerides, total cholesterol, LDL-C, and HDL-C in the magnesium group were comparable to those in the placebo group, showing no significant differences. Additionally, magnesium supplementation led to significant reductions in MDA, TAC, and hs-CRP compared to placebo, while GSH and nitric oxide levels remained similar between both groups with no significant differences.
Conclusion: The findings of this study suggest that magnesium supplementation over a 14-week period positively impacts metabolic profiles and intrauterine growth in pregnant women at risk of IUGR.
Keywords: Intrauterine Growth Restriction (IUGR), Magnesium, Insulin Resistance, Inflammatory Factors
Full-Text [PDF 452 kb]   (152 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2024/01/10 | Revised: 2024/10/23 | Accepted: 2024/09/16 | Published: 2024/10/23
References
1. Amruta N, Kandikattu HK, Intapad S. Cardiovascular Dysfunction in Intrauterine Growth Restriction. Curr Hypertens Rep. 2022; 24(12): 693-708. doi:10.1007/s11906-022-01228-y
2. Manapurath R, Gadapani B, Pereira-da-Silva L. Body composition of infants born with intrauterine growth restriction: A systematic review and meta-analysis. Nutrients. 2022; 14(5): 1085. doi:10.3390/nu14051085
3. Armengaud J, Yzydorczyk C, Siddeek B, Peyter A, Simeoni U. Intrauterine growth restriction: Clinical consequences on health and disease at adulthood. Reprod Toxicol. 2021; 99: 168-76. doi:10.1016/j.reprotox.2020.10.005
4. Wan L, Luo K, Chen P. Mechanisms underlying neurologic Injury in intrauterine growth restriction. J Child Neurol. 2021; 36(9): 776-84. doi:10.1177/0883073821999896
5. Marín R, Abad C, Rojas D, Chiarello DI, Rangel H, Teppa-Garrán A, et al. Magnesium salts in Pregnancy. JTEMIN. 2023:100071. doi:10.1016/j.jtemin.2023.100071
6. Fanni D, Gerosa C, Nurchi V, Manchia M, Saba L, Coghe F, et al. The role of magnesium in pregnancy and in fetal programming of adult diseases. Biol. Trace Elem Res. 2021; 199: 3647-57. doi:10.1007/s12011-020-02513-0
7. Maret W. Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals. Biometals. 2009; 22: 149-57. doi:10.1007/s10534-008-9186-z
8. Li B, Chang S, Liu C, Zhang M, Zhang L, Liang L, et al. Low maternal dietary folate alters retrotranspose by methylation regulation in intrauterine growth retardation (IUGR) fetuses in a mouse model. Medical Science Monitor. Int J Clin Exp Med. 2019; 25: 3354. doi:10.12659/MSM.914292
9. Dempsey C, McCormick NH, Croxford TP, Seo YA, Grider A, Kelleher SL. Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. J Nutr. 2012; 142(4): 655-60. doi:10.3945/jn.111.150623
10. McCormick NH, King J, Krebs N, Soybel DI, Kelleher SL. Redistribution of tissue zinc pools during lactation and dyshomeostasis during marginal zinc deficiency in mice. J Trace Elem Med Biol. 2015; 29: 170-5. doi:10.1016/j.jtemb.2014.06.002
11. Tian X, Anthony K, Neuberger T, Diaz FJ. Preconception zinc deficiency disrupts postimplantation fetal and placental development in mice. Biol Reprod. 2014; 90(4):83, 1-12. doi:10.1095/biolreprod.113.113910
12. Farag M, El-Baz Z, Ahmed EH. Comparison of maternal serum magnesium level in eclampsia, preeclampsia and normal pregnant women admitted to El-Shatby Maternity Hospital. Evid Bas Women Health J. 2022; 12(4): 332-7. doi:10.21608/ebwhj.2022.163590.1201
13. Danesh A, Janghorbani M, Mohammadi B. Effects of zinc supplementation during pregnancy on pregnancy outcome in women with history of preterm delivery: a double-blind randomized, placebo-controlled trial. J Matern Fetal Neonatal Med. 2010; 23(5): 403-8. doi:10.3109/14767050903165214
14. Karamali M, Heidarzadeh Z, Seifati S-M, Samimi M, Tabassi Z, Talaee N, et al. Zinc supplementation and the effects on pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Exp Clin Endocrinol. 2015; 124(01): 28-33. doi:10.1055/s-0035-1564146
15. Hashemipour S, Seidjavadi EH, Maleki F, Esmailzadehha N, Movahed F, Yazdi Z. Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. Pediatr Neonatol. 2018; 59(6): 567-72. doi:10.1016/j.pedneo.2018.01.008
16. Golic M, Stojanovska V, Bendix I, Wehner A, Herse F, Haase N, et al. Diabetes mellitus in pregnancy leads to growth restriction and epigenetic modification of the Srebf2 gene in rat fetuses. Hypertension. 2018;71(5): 911-20doi:10.1161/HYPERTENSIONAHA.117.10782
17. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Biol. Trace Elem Res. 2016; 170: 271-8. doi:10.1007/s12011-015-0480-7
18. Rodríguez-Morán M, Simental-Mendía LE, Gamboa-Gómez CI, Guerrero-Romero F. Oral magnesium supplementation and metabolic syndrome: a randomized double-blind placebo-controlled clinical trial. Adv Chronic Kidney Dis. 2018; 25(3):261-6. doi:10.1053/j.ackd.2018.02.011
19. Zarean E, Tarjan A. Effect of magnesium supplement on pregnancy outcomes: a randomized control trial. Adv Biomed Res. 2017; 6. doi:10.4103/2277-9175.213879
20. Shaikh K, Das CM, Baloch GH, Abbas T, Fazlani K, Jaffery MH, et al. Magnesium associated complications in pregnant women. World Appl Sci J. 2012; 17(9):1074-78.
21. Kazemi-Darabadi S, Akbari G. Evaluation of magnesium sulfate effects on fetus development in experimentally induced surgical fetal growth restriction in rat. J Matern Fetal Neonatal Med. 2020; 33(14): 2459-65. doi:10.1080/14767058.2018.1554048
22. de Araújo CA, Ray JG, Figueiroa JN, Alves JG. BRAzil magnesium (BRAMAG) trial: a double-masked randomized clinical trial of oral magnesium supplementation in pregnancy. BMC. 2020; 20: 1-7. doi:10.1186/s12884-020-02935-7
23. UN D. Delta 6 desaturase as the target of the beneficial actions of magnesium. Med Sci Monit. 2010;16.
24. Niu Y, He J, Zhao Y, Shen M, Zhang L, Zhong X, et al. Effect of curcumin on growth performance, inflammation, insulin level, and lipid metabolism in weaned piglets with IUGR. Animals. 2019; 9(12): 1098. doi:10.3390/ani9121098
25. Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, et al. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature. 2011; 475(7357): 471-6. doi:10.1038/nature10246
26. Roman A, Desai N, Rochelson B, Gupta M, Solanki M, Xue X, et al. Maternal magnesium supplementation reduces intrauterine growth restriction and suppresses inflammation in a rat model. Am J Obstet Gynecol. 2013; 208(5): 383. e1-7. doi:10.1016/j.ajog.2013.03.001
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Mesdaghinia E, Hedayati P, Soheilipour N, Gilasi H R, Zarei Yazdeli M. Growth response to magnesium supplementation in pregnant women at risk of intrauterine growth restriction (IUGR). Feyz Med Sci J 2024; 28 (4) :392-399
URL: http://feyz.kaums.ac.ir/article-1-5096-en.html


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Volume 28, Issue 4 (Bimothly 2024) Back to browse issues page
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