1. Roshandel G, Ferlay J, Ghanbari-Motlagh A, Partovipour E, Salavati F, Aryan K, et al. Cancer in Iran 2008 to 2025: Recent incidence trends and short-term predictions of the future burden. Int J Cancer 2021;149(3): 594-605. doi:10.1002/ijc.33574 PMid:33884608

2. Colorectal cancer: World Health Organization. Available at: https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer#:~:text=Colon%20cancer%20is%20the%20second,and%20mortality%20rates%20were%20observed.

3. Nemeth K, Bayraktar R, Ferracin M, Calin GA. Non-coding RNAs in disease: from mechanisms to therapeutics. Nature Reviews Genetics 2023. doi:10.1038/s41576-023-00662-1 PMid:37968332

4. Egloff S, Studniarek C, Kiss T. 7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features. Transcription 2018;9(2):95-101. doi:10.1080/21541264.2017.1344346 PMid:28820318 PMCid:PMC5834218

5. Camara MB, Sobeh AM, Eichhorn CD. Progress in 7SK ribonucleoprotein structural biology. Front Mol Biosci 2023;10:1154622. doi:10.3389/fmolb.2023.1154622 PMid:37051324 PMCid:PMC10083321

6. Quaresma AJ, Bugai A, Barboric M. Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb. Nucleic Acids Res 2016;44(16): 7527-39. doi:10.1093/nar/gkw585 PMid:27369380 PMCid:PMC5027500

7. Zhou Q, Li T, Price DH. RNA polymerase II elongation control. Annu Rev Biochem 2012;81:119-43. doi:10.1146/annurev-biochem-052610-095910 PMid:22404626 PMCid:PMC4273853

8. Eilebrecht S, Bécavin C, Léger H, Benecke B-J, Benecke A. HMGA1-dependent and independent 7SK RNA gene regulatory activity. RNA Biol 2011;8(1):143-57. doi:10.4161/rna.8.1.14261 PMid:21282977

9. Eilebrecht S, Brysbaert G, Wegert T, Urlaub H, Benecke B-J, Benecke A. 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation. Nucleic Acids Research 2010;39(6): 2057-72. doi:10.1093/nar/gkq1153 PMid:21087998 PMCid:PMC3064786

10. Zhao L, Liu Y, Tong D, Qin Y, Yang J, Xue M, et al. MeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways. EBioMedicine 2017;16:87-100. doi:10.1016/j.ebiom.2017.01.021 PMid:28131747 PMCid:PMC5474507

11. Wang Y, Hu L, Zheng Y, Guo L. HMGA1 in cancer: Cancer classification by location. J Cell Mol Med 2019;23 (4): 2293-302. doi:10.1111/jcmm.14082 PMid:30614613 PMCid:PMC6433663

12. Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. eLife 2014;3:e02907. doi:10.7554/eLife.02907 PMid:25053741 PMCid:PMC4126343

13. Tan Justin L, Fogley Rachel D, Flynn Ryan A, Ablain J, Yang S, Saint-André V, et al. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell 2016; 62(1):34-46. doi:10.1016/j.molcel.2016.03.013 PMid:27058786 PMCid:PMC4836061

14. Najafi N, Gharib MH, Nematollahi N, Mehravar F. Preoperative evaluation of pelvic MRI findings in patients with rectosigmoid cancer in Golestan province (north of Iran). Novel Clin Med. 2022;1(3):127-34. doi: 10.22034/ncm.2022.337938.1041

15. Abasi M, Bazi Z, Mohammadi-Yeganeh S, Soleimani M, Haghpanah V, Zargami N, et al. 7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells. Med Oncol 2016;33(11):128. doi:10.1007/s12032-016-0841-x PMid:27752877

16. Zhang B, Min S, Guo Q, Huang Y, Guo Y, Liang X, et al. 7SK Acts as an Anti-tumor Factor in Tongue Squamous Cell Carcinoma. Front Genet 2021;12: 642969. doi:10.3389/fgene.2021.642969 PMid:33868377 PMCid:PMC8047107

17. Farhadi S, Mohammadi-Yeganeh S, Kiani J, Hashemi SM, Koochaki A, Sharifi K, et al. Exosomal delivery of 7SK long non-coding RNA suppresses viability, proliferation, aggressiveness and tumorigenicity in triple negative breast cancer cells. Life Sci 2023;322:121646. doi:10.1016/j.lfs.2023.121646 PMid:37011870

18. Eilebrecht S, Brysbaert G, Wegert T, Urlaub H, Benecke B-J, Benecke A. 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation. Nucleic Acids Res 2011;39(6): 2057-72 doi:10.1093/nar/gkq1153 PMid:21087998 PMCid:PMC3064786

19. Grade M, Hörmann P, Becker S, Hummon AB, Wangsa D, Varma S, et al. Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res 2007;67(1): 41-56. doi:10.1158/0008-5472.CAN-06-1514PMid:17210682 PMCid:PMC4721580

20. Xian L, Georgess D, Huso T, Cope L, Belton A, Chang Y-T, et al. HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche. Nature Communications 2017;8 (1):15008. doi:10.1038/ncomms15008 PMid:28452345 PMCid:PMC5414379

21. E MP, Liu T, Zhang X, Yang H, Wang J, Huang R, et al. High-mobility group A1 (HMGA1) gene expressions in various colorectal cancer cell lines and correlation with prognosis. Transl Cancer Res 2020; 9(2): 763-73. doi:10.21037/tcr.2019.12.10 PMid:35117422 PMCid:PMC8798761

22. Belton A, Gabrovsky A, Bae YK, Reeves R, Iacobuzio-Donahue C, Huso DL, et al. HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells. PLOS ONE 2012; 7(1): e30034. doi:10.1371/journal.pone.0030034 PMid:22276142 PMCid:PMC3262796

23. Toden S, Zumwalt TJ, Goel A. Non-coding RNAs and potential therapeutic targeting in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2021;1875(1):188491. doi:10.1016/j.bbcan.2020.188491 PMid:33316377 PMCid:PMC7856203

24. Camara MB, Sobeh AM, Eichhorn CD. Progress in 7SK ribonucleoprotein structural biology. 2023;10. doi:10.3389/fmolb.2023.1154622 PMid:37051324 PMCid:PMC10083321

25. Lu Y, Huang W, Li M, Zheng A. Exosome-Based Carrier for RNA Delivery: Progress and Challenges. Pharmaceutics 2023;15(2). doi:10.3390/pharmaceutics15020598 PMid:36839920 PMCid:PMC9964211

26. Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, et al. Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. Nature Biomedical Engineering 2020;4(1):69-83. doi:10.1038/s41551-019-0485-1 PMid:31844155 PMCid:PMC7080209

27. Zeng H, Guo S, Ren X, Wu Z, Liu S, Yao X. Current Strategies for Exosome Cargo Loading and Targeting Delivery. Cells. 2023; 12(10). doi:10.3390/cells12101416 PMid:37408250 PMCid:PMC10216928

28. Khazaei-Poul Y, Shojaei S, Koochaki A, Ghanbarian H, Mohammadi-Yeganeh S. Evaluating the influence of Human Umbilical Cord Mesenchymal Stem Cells-derived exosomes loaded with miR-3182 on metastatic performance of Triple Negative Breast Cancer cells. Life Sci 2021;286: 120015. doi:10.1016/j.lfs.2021.120015 PMid:34614416

29. Rezaei-Tazangi F, Alidadi H, Samimi A, Karimi S, Kahorsandi L. Effects of Wharton's jelly mesenchymal stem cells-derived secretome on colon carcinoma HT-29 cells. Tissue Cell 2020;67:101413. doi:10.1016/j.tice.2020.101413 PMid:32835945

30. Jahangiri B, Khalaj-Kondori M, Asadollahi E, Purrafee Dizaj L, Sadeghizadeh M. MSC-Derived exosomes suppress colorectal cancer cell proliferation and metastasis via miR-100/mTOR/miR-143 pathway. Int J Pharm 2022; 627: 122214. doi:10.1016/j.ijpharm.2022.122214 PMid:36152993

31. Wu XB, Liu Y, Wang G-H, Xu X, Cai Y, Wang H-Y, et al. Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation. Sci Rep 2016;6(1):21420. doi:10.1038/srep21420 PMid:26892992 PMCid:PMC4759824

32. Li H, Li F. Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p. Br J Cancer 2018;119(6):744-55. doi:10.1038/s41416-018-0254-z PMid:30220706 PMCid:PMC6173771

33. Wu S, Ju GQ, Du T, Zhu YJ, Liu GH. Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS One 2013;8(4):e61366. doi:10.1371/journal.pone.0061366 PMid:23593475 PMCid:PMC3625149

34. Li D, Lin F, Li G, Zeng F. Exosomes derived from mesenchymal stem cells curbs the progression of clear cell renal cell carcinoma through T-cell immune response. Cytotechnology 2021; 73(4):593-604.doi:10.1007/s10616-021-00480-5 PMid:34349349 PMCid:PMC8319245

35. Zhao X, Wu X, Qian M, Song Y, Wu D, Zhang W. Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells. Cancer Lett 2018;428:34-44. doi:10.1016/j.canlet.2018.04.026 PMid:29702191

36. Zhou X, Li T, Chen Y, Zhang N, Wang P, Liang Y, et al. Mesenchymal stem cell derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway. Int J Oncol 2019;54(5):1843-52. doi:10.3892/ijo.2019.4747 PMid:30864702

37. Du L, Tao X, Shen X. Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway. Breast Cancer 2021; 28(4):829-37. doi:10.1007/s12282-021-01218-z PMid:33770377