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:: Volume 27, Issue 3 (August-September 2023) ::
Feyz Med Sci J 2023, 27(3): 244-253 Back to browse issues page
The effect of a high-intensity interval training with Portulaca oleracea supplementation on Irisin and TLR4 in the liver tissue of rats with non-alcoholic fatty liver disease
Majid Farah Nia , Mohammad Raza Hosseinabadi * , Mehdi Zarei , Mahmood Soltani
Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, I.R. Iran. , mrhoseinabadi@gmail.com
Abstract:   (1121 Views)
Background: Lifestyle modification through dietary interventions and exercise training is still one of the most effective ways to treat non-alcoholic fatty liver disease. The aim of this study was to investigate the effect of a high-intensity interval training along with Portulaca oleracea supplementation on Irisin and TLR4 in the liver tissues of rats with non-alcoholic fatty liver disease.
Materials and Methods: In this experimental study, 30 male Wistar rats were divided into two groups: non-alcoholic fatty liver disease (n=25) and healthy control (n=5). Non-alcoholic fatty liver was induced by 12 weeks of high-fat diet. After confirming non-alcoholic fatty liver disease, rats (n=20) were assigned into four subgroups; non-alcoholic fatty liver control group (n=5), Portulaca oleracea supplement group (n=5), training group (n=5) and training group + Portulaca oleracea supplement (n=5). Portulaca oleracea supplement was given daily and a high-intensity interval training was presented for 8 weeks, 5 sessions per week. The amounts of Irisin and TLR4 in liver tissue were measured using the sandwich ELISA method.

Results: Irisin levels were significantly higher in the training+Portulaca oleracea supplement group compared to the fatty liver control group (P=0.001), the interval training group (P=0.018) and Portulaca oleracea supplement group (P=0.033). The TLR4 levels in the training+Portulaca oleracea supplement group (P=0.007) and the high intensity interval training group (P=0.045) were significantly lower than the fatty liver control group.
Conclusion: High-intensity interval training along with Portulaca oleracea supplementation leads to increases in Irisin release and decreases in the TLR4 levels in the liver tissue of rats with non-alcoholic fatty liver disease, which may be effective in improving non-alcoholic fatty liver disease.
Keywords: High-intensity interval training, Portulaca oleracea, Non-alcoholic fatty liver disease, Irisin, TLR4
Full-Text [PDF 396 kb]   (520 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2023/05/15 | Revised: 2023/10/31 | Accepted: 2023/07/2 | Published: 2023/08/5
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Farah Nia M, Hosseinabadi M R, Zarei M, Soltani M. The effect of a high-intensity interval training with Portulaca oleracea supplementation on Irisin and TLR4 in the liver tissue of rats with non-alcoholic fatty liver disease. Feyz Med Sci J 2023; 27 (3) :244-253
URL: http://feyz.kaums.ac.ir/article-1-4879-en.html


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Volume 27, Issue 3 (August-September 2023) Back to browse issues page
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