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:: Volume 27, Issue 3 (August-September 2023) ::
Feyz Med Sci J 2023, 27(3): 236-243 Back to browse issues page
Interaction effects of cerium oxide nanoparticles and trans-anethole on improving the function of damaged sciatic nerve in rat model
Zahra Naseri , Fariba Mamoudi * , Khadijeh Haghighat
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, I.R. Iran. , f.mahmoudi@uma.ac.ir
Abstract:   (1478 Views)
Background: Sciatica is a peripheral nervous system disorder that affects many people throughout the world. New therapeutic approaches such as nanomedicines and plant derivatives with less side effects can be used to improve nerve tissue. Trans-anethole is a part of phytoestrogen derived from anise and fennel, and has strong steroidogenic and anti-inflammatory effects. Cerium oxide nanoparticles also have antioxidant properties. In this study, the interaction effects of cerium oxide nanoparticles and trans-anethole investigated on improving the function of the damaged sciatic nerve in a rat mode.
Materials and method: In this study, 20 male rats weighing 250-300 g divided into five groups. The control group and the sciatica model group received saline. One group of sciatica model received simultaneous 125 mg/kg trans-anethole or 20 mg/kg cerium oxide nanoparticles, and the other group of sciatica model received simultaneous 250 mg/kg trans-anethole or 20 mg/kg cerium oxide nanoparticles (IP). Behavioral tests (Sensory and motor) taken from each group and muscle tissue removed to evaluate the atrophy rate.
Results: The results showed that the simultaneous injection of trans-anethole and cerium oxide nanoparticles improved the damaged sciatic nerve compared to the sciatica model group. Also, the index of sciatica performance and sensory recovery was better in rats receiving trans-anethole and cerium oxide nanoparticles at the same time compared to the sciatica model group.
Conclusion: Trans-anethole and cerium oxide nanoparticles, due to their antioxidant and neuroprotective properties, may be involved in the recovery of the damaged sciatic nerve by synergizing each other's effects.
Keywords: Sciatic, Trans-anethole, Cerium oxide nanoparticles
Full-Text [PDF 405 kb]   (567 Downloads)    
Type of Study: Research | Subject: General
Received: 2023/03/17 | Revised: 2023/10/31 | Accepted: 2023/06/21 | Published: 2023/08/5
References
1. Li R, Liu Z, Pan Y, Chen L, Zhang Z, Lu L. Peripheral nerve injuries treatment: a systematic review. Cell Biochemistry Biophysics 2014; 68: 449-54.
2. Seddighi A, Nikouei A, Saied Seddighi A, Reza Zali A, Mahmood Tabatabaei S, Reza Sheykhi A, et al. Peripheral nerve injury: a review article. Int Clin Neurosci J 2016; 3(1): 1-6.
3. Suhail S, Jamil SS, Khan S, Jilani S, Ansari S. Concept of Irq al-nasa (sciatica) and its management in Unani system of medicine.
4. Ostelo RW. Physiotherapy management of sciatica. J Physiotherapy 2020; 66(2): 83-8.
5. Yu C, Wang X, Qin J. Effect of necrostatin-[1 on sciatic nerve crush injury in rat models. J Orthopaedic Surgery Res 2023; 18(1): 1-9.
6. Rosic G, Selakovic D. Nanoparticle-Induced Toxicities: An Update on the Role of Oxidative Stress. Hindawi; 2022.
7. Zhang M, Zhang C, Zhai X, Luo F, Du Y, Yan C. Antibacterial mechanism and activity of cerium oxide nanoparticles. Sci China Mater 2019; 62(11): 1727-39.
8. Rajeshkumar S, Naik P. Synthesis and biomedical applications of cerium oxide nanoparticles–a review. Biotechnol Reports 2018; 17: 1-5.
9. Dhall A, Self W. Cerium oxide nanoparticles: a brief review of their synthesis methods and biomedical applications. Antioxidants 2018; 7(8): 97.
10. Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med 2004; 116(7): 478-85.
11. Kim KY, Lee HS, Seol GH. Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease. Biomedicine Pharmacotherapy 2017; 91: 925-30.
12. da Silva-Alves KS, Ferreira-da-Silva FW, Coelho-de-Souza AN, Albuquerque AAC, do Vale OC, Leal-Cardoso JH. Essential oil of Croton zehntneri and its main constituent anethole block excitability of rat peripheral nerve. Planta Medica 2015; 81(04): 292-7.
13. Matboli M, Hasanin AH, Hamady S, Khairy E, Mohamed RH, Aboul-Ela YM, et al. Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury. Biomedicine Pharmacotherapy 2022; 150: 113070.
14. Aprotosoaie AC, Costache I-I, Miron A. Anethole and its role in chronic diseases. Drug Discovery from Mother Nature 2016: 247-67.
15. Wang B, Zhang G, Yang M, Liu N, Li YX, Ma H, et al. Neuroprotective effect of anethole against neuropathic pain induced by chronic constriction injury of the sciatic nerve in mice. Neurochemical Res 2018; 43: 2404-22.
16. Azimpour M, Mahmoudi F, Abdolmaleki A, Bayrami A. Thyroxine accelerates functional recovery in a rat model of sciatic nerve crush. Turk Neurosurg 2022; 32(2): 298-304.
17. Ghayour MB, Abdolmaleki A, Behnam-Rassouli M. The effect of Riluzole on functional recovery of locomotion in the rat sciatic nerve crush model. Eur J Trauma Emergency Surgery 2017; 43: 691-9.
18. Ryu S, Seol GH, Park H, Choi I-Y. Trans-anethole protects cortical neuronal cells against oxygen–glucose deprivation/reoxygenation. Neurological Sci 2014; 35: 1541-7.
19. Soluki M, Mahmoudi F, Abdolmaleki A, Asadi A, Sabahi Namini A. Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury. Br J Neurosurg 2020:1-6.
20. Magaz A, Faroni A, Gough JE, Reid AJ, Li X, Blaker JJ. Bioactive silk‐based nerve guidance conduits for augmenting peripheral nerve repair. Advanced Healthcare Materials 2018; 7(23): 1800308.
21. Koh GP, Fouad C, Lanzinger W, Willits RK. Effect of intraoperative electrical stimulation on recovery after rat sciatic nerve isograft repair. Neurotrauma Reports 2020; 1(1): 181-91.
22. Mo Y, Liu B, Qiu S, Wang X, Zhong L, Han X, et al. Down‐regulation of microRNA‐34c‐5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve. J Neurochemistry 2020; 154(3): 301-15.
23. Leskovar A, Moriarty LJ, Turek JJ, Schoenlein IA, Borgens RB. The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J Experimental Biol 2000; 203(12): 1783-95.
24. Moradi J, Abbasipour F, Zaringhalam J, Maleki B, Ziaee N, Khodadoustan A, et al. Anethole, a medicinal plant compound, decreases the production of pro-inflammatory TNF-α and IL-1β in a rat model of LPS-induced periodontitis. Iran J Pharmaceutical Res 2014;13(4):1319.
25. Zheng Q, Fang Y, Zeng L, Li X, Chen H, Song H, et al. Cytocompatible cerium oxide-mediated antioxidative stress in inhibiting ocular inflammation-associated corneal neovascularization. J Materials Chemistry B 2019;7(43):6759-69.
26. Jahromi Z, Mohammadghasemi F, Moharrami Kasmaie F, Zaminy A. Cinnamaldehyde enhanced functional recovery after sciatic nerve crush injury in rats. Cells Tissues Organs 2020;209(1):43-53.
27. Kongsui R, Surapinit S, Promsrisuk T, Thongrong S. Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury. Brazilian J Med Biological Res 2023; 56.
28. Ritter AMV, Ames FQ, Otani F, de Oliveira RMW, Cuman RKN, Bersani-Amado CA. Effects of anethole in nociception experimental models. Evidence-Based Complementary Alternative Med 2014; 2014.
29. Pagliari F, Mandoli C, Forte G, Magnani E, Pagliari S, Nardone G, et al. Cerium oxide nanoparticles protect cardiac progenitor cells from oxidative stress. ACS Nano 2012; 6(5): 3767-75.
30. Alypoor S, Abdolmaleki A, Mamoudi F, Haghighat K, Soluki M. Evaluation of the Neuroprotective Effect of Eugenol on the Improvement of Sciatic Nerve Injury in Rats. Iran J Toxicol:0-.
31. Zhang D, Jing B, Chen Zn, Li X, Shi Hm, Zheng Yc, et al. Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4/NF‐κB pathway. CNS Neurosci Therapeutics 2023.
32. Selvaraj V, Nepal N, Rogers S, Manne ND, Arvapalli R, Rice KM, et al. Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. Data Brief 2015; 4: 105-15.
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Naseri Z, Mamoudi F, Haghighat K. Interaction effects of cerium oxide nanoparticles and trans-anethole on improving the function of damaged sciatic nerve in rat model. Feyz Med Sci J 2023; 27 (3) :236-243
URL: http://feyz.kaums.ac.ir/article-1-4846-en.html


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Volume 27, Issue 3 (August-September 2023) Back to browse issues page
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