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:: Volume 27, Issue 3 (August-September 2023) ::
Feyz Med Sci J 2023, 27(3): 254-261 Back to browse issues page
The effect of high-intensity interval training along with curcumin consumption on mitochondrial caspase 3 and 9 gene expression of cardiomyocyte in male rat of the stroke model
Alireza Rouzbahani , Saleh Rahmati-Ahmadabad *
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, I.R. Iran. , salehrahmati@pardisiau.ac.ir
Abstract:   (835 Views)
Background: Apoptosis is a protective cellular process and physical activity and curcumin may affect some signaling pathways related to apoptosis. The aim of the present study was to evaluate the effect of high-intensity interval training (HIIT) and curcumin consumption on mitochondrial caspase 3 and 9 gene expression of cardiomyocyte in male rat of the stroke model.
Materials and Methods: In this experimental study, 32 male rats with myocardial infarction were assigned randomly into 4 equal groups (n=8) of HIIT, supplement, control, and supplement+HIIT. The HIIT groups were subjected to high-intensity interval training (10 bouts of 4-minute activity with an intensity of 85-90% of VO2max) for 8 weeks. The amount of 15 mg of pure curcumin per kilogram of body weight was given by a gavage to the supplement and HIIT+supplement groups, 5 days a week. All rats were anesthetized by intraperitoneal injection of ketamine and xylazine, 48 hours after the last training session, then surgery and dissection of the rats were performed.
Results: The results showed a significant decrease in the expression of caspase 3 and 9 genes in the HIIT and HIIT+supplement groups compared to the control and supplement groups.
Conclusion: It seems that HIIT and curcumin consumptions lead to a reduction of mitochondrial apoptosis in cardiac muscle. The present findings show that the expression of caspase 3 and 9 in cardiac tissue is a trainable factor.
Keywords: HIIT, Curcumin, Cardiac infarction, Apoptosis, Rat
Full-Text [PDF 315 kb]   (455 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2023/01/23 | Revised: 2023/10/31 | Accepted: 2023/07/10 | Published: 2023/08/5
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Rouzbahani A, Rahmati-Ahmadabad S. The effect of high-intensity interval training along with curcumin consumption on mitochondrial caspase 3 and 9 gene expression of cardiomyocyte in male rat of the stroke model. Feyz Med Sci J 2023; 27 (3) :254-261
URL: http://feyz.kaums.ac.ir/article-1-4807-en.html


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Volume 27, Issue 3 (August-September 2023) Back to browse issues page
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