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The effect of 8 weeks of consumption of cinnamon hydroalcoholic extract and aerobic exercise on the levels of SPARC, AMPK and GLUT4 in soleus muscle of type 2 diabetic rats
Mehdi Abbasi Moghadam , Vahid Valipour Dehnou * , Mahdieh Molanouri Shamsi
Lorestan University , valipour.v@lu.ac.ir
Abstract:   (196 Views)
Background: Considering the hypoglycemic role of cysteine-rich acidic secreted protein (SPARC) and its effect on AMPK phosphorylation and GLUT4 expression, the aim of the present study was to investigate the effect of aerobic exercise with cinnamon extract supplementation on SPARC, AMPK and GLUT4 levels in type 2 diabetic rats.
Materials and methods: 35 eight-week-old male Wistar rats were randomly and equally divided into five groups: control (C), diabetes (D), diabetes-supplement (DS), diabetes-exercise (DE), and diabetes-exercise-supplement (DES). The training program was performed 5 sessions per week for 8 weeks. Rats in DS and DES groups received 200 mg/kg of CE daily by gavage, and rats in C and DE groups received water during this period.
Results: Blood glucose was decreased in the DS, DE, and DES groups. SPARC, AMPK, and GLUT4 protein levels and weight significantly reduced in the D group. Also, GLUT4 levels in the DS group increased significantly. However, the SPARC, AMPK, and GLUT4 protein levels were significantly increased in both the DE and DES groups.
Conclusion: CE only increased GLUT4 but exercise increased the SPARC, AMPK, and GLUT4 in diabetic rats. However, exercise with CE had significantly greater effects on the SPARC, AMPK, and GLUT4 in diabetic rats and could be very useful in the treatment of hyperglycemia in diabetic patients.
Keywords: Aerobic exercise, Cinnamon extract, SPARC, AMPK, GLUT4, Type 2 diabetes
Type of Study: Applicable | Subject: General
Received: 2022/09/19 | Accepted: 2022/12/5
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