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:: Volume 27, Issue 2 (Bimonthly 2023) ::
Feyz Med Sci J 2023, 27(2): 176-185 Back to browse issues page
The effect of exercise training and olive oil consumption on the spatial learning, genes expression of the AKT and caspase3 of rats with parkinson's disease
Mansooreh Shamsi-Soosahab , Alireza Elmieh * , Ramin Shabani
Department of Physical Education, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran. , elmieh@iaurasht.ac.ir
Abstract:   (1063 Views)
Background: Parkinson's disease is a progressive and destructive disorder of the central nervous system. This study aimed to determine the effect exercise training and olive oil consumption on genes expression of the AKT¸ caspase3 and the spatial learning of rats with parkinson's disease
Materials and Methods: in this study, 30 rats were divided into 5 groups of 6: healthy control¸ parkinson´s control¸ parkinson´s+olive oil¸ parkinson´s+exercise training¸ parkinson´s+exercise training+olive oil.  The rats were fed 0.4 ml of olive oil daily for 8 weeks. Aerobic training was performed 5 days a week for 30 minutes and at a speed of 11 meters per minute. Resistance exercise begin with %30 of the rat´s weight and it reached %100 of the rat´s weight in the eighth week. The gene expression of AKT and caspase3 was measured through PCR-real time and spatial learning using radial maze. Data analyzed using one-way of variance and Thomhan's follow up test.
Result: Increase in AKT genes expressin, reduced in caspase3 expression and spatial learning improvement significantly observed in exercise training and exercise training+olive oil compared to the parkinson's control group (P<0.05).
Conclusion: exercise training with and without olive oil consumpsion can be effective in improving spatial learning by increasing AKT and decreasing caspase3. 
Keywords: Parkinson's rats, Aerobic resistance exercise, Olive oil, AKT¸ Caspase3
Full-Text [PDF 372 kb]   (657 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/09/13 | Revised: 2023/07/25 | Accepted: 2023/05/8 | Published: 2023/06/14
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Shamsi-Soosahab M, Elmieh A, Shabani R. The effect of exercise training and olive oil consumption on the spatial learning, genes expression of the AKT and caspase3 of rats with parkinson's disease. Feyz Med Sci J 2023; 27 (2) :176-185
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Volume 27, Issue 2 (Bimonthly 2023) Back to browse issues page
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