[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Biochemistry and Nutrition in Metabolic Diseases
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 26, Issue 6 (Bimonthly 2022) ::
Feyz Med Sci J 2022, 26(6): 629-636 Back to browse issues page
The effect of Zizyphus jujube aqueous extract on learning, memory, locomotor activity and brain malondialdehyde level in rats with Parkinson’s disease
Esmail Alipour-Nosrani , Mohsen Ghazanfari , Masoumeh Eslahi , Mohammad Hajijafari , Mohsen Taghizadeh *
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran. , taghizadeh_m@kaums.ac.ir
Abstract:   (1094 Views)
Background: Parkinson’s disease (PD) as a progressive disorder caused by degeneration of dopamine (DA) neurons leads to bradykinesia, tremor, and cognitive dysfunction. The administration of Z. jujuba in animal models of nervous system disorder had favorable effects on memory ability and oxidative stress biomarkers. Accordingly, we assessed the influence of Z. jujuba aqueous extract administration on learning, memory, locomotor activity and oxidative stress biomarker in rats with Parkinson’s disease.
Materials and Methods: In this study forty adult Wistar rats allocated into four groups were sham group, untreated Parkinson study group and two groups treated with aqueous extract of Z. jujube at two different concentrations of 500 and 1000 mg/kg/days. PD induction was done by injecting 6-hydroxydopamine (6-OHDA). Rotations activity was assessed by injection of apomorphine. Morris water maze was utilized to evaluate spatial learning and memory. Also, oxidative stress was evaluated by malondialdehyde (MDA) biomarker.
Results: Our data showed that the 6-OHDA-induced PD led to the learning, memory and rotations activity dysfunctions. Administration of 1000 mg/kg of Z. jujube improved the learning and memory (P<0.0001). In addition, 500 and 1000 mg/kg of Z. jujube decreased the apomorphine-induced rotations (P<0.0001). Also, Z. jujube decreased malondialdehyde level in midbrain and hippocampus (P<0.05).
Conclusion: aqueous extract of Z. jujube administrated by the animal model of PD can has favorable potentials on memory, learning, apomorphine-induced rotations and brain malondialdehyde level.
Keywords: Ziziphus jujube, Learning, Memory, Motor disorders, Parkinson’s disease
Full-Text [PDF 383 kb]   (576 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/08/31 | Revised: 2023/03/11 | Accepted: 2022/12/5 | Published: 2023/02/22
References
1. Salawu F, Danburam A, Olokoba A. Non-motor symptoms of Parkinson's disease: diagnosis and management. Niger J Med 2010; 19(2): 126-31.
2. Zhang P, Tian B. Metabolic syndrome: an important risk factor for Parkinson’s disease. Oxid Med Cell Longev 2014; 2014: 729194.
3. Van Kampen JM, Robertson HA. The BSSG rat model of Parkinson’s disease: progressing towards a valid, predictive model of disease. Epma J 2017; 8(3): 261-71.
4. Aarsland D, Brønnick K, Larsen J, Tysnes O, Alves G. Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study. Neurol 2009; 72(13): 1121-6.
5. Pagonabarraga J, Kulisevsky J. Cognitive impairment and dementia in Parkinson's disease. Neurobiol Dis 2012; 46(3): 590-6.
6. Aarsland D, Kurz MW. The epidemiology of dementia associated with Parkinson disease. J Neurological Sci 2010; 289(1-2): 18-22.
7. Schelp AO, Mendes-Chiloff CL, Bazan R, Paduan VC, Pioltini ABM. Metabolic syndrome and dementia associated with Parkinson's disease: impact of age and hypertension. Arq Neuropsiquiatr 2012; 70(2): 114-8.
8. Chen CM, Liu JL, Wu YR, Chen YC, Cheng HS, Cheng ML, et al. Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease. Neurobiol Dis 2009; 33(3): 429-35.
9. Mansouri MT, Farbood Y, Sameri MJ, Sarkaki A, Naghizadeh B, Rafeirad M. Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats. Food Chemistry 2013; 138(2-3): 1028-33.
10. Taghizadeh M, Tamtaji OR, Dadgostar E, Kakhaki RD, Bahmani F, Abolhassani J, et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Neurochem Int 2017; 108: 183-9.
11. Choi HS, Park MS, Kim SH, Hwang BY, Lee CK, Lee MK. Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Molecules 2010; 15(4): 2814-24.
12. Majid T, Masoud A, Mohamad HM, Bahram R, Mehrnoush M, Farzam S, et al. Protective effects of Ziziphus jujuba fruit extract against ethanol-induced hippocampal oxidative stress and spatial memory impairment in rats. J Med Plants Res 2011; 5(6): 915-21.
13. Lee HE, Lee SY, Kim JS, Park SJ, Kim JM, Lee YW, et al. Ethanolic extract of the seed of Zizyphus jujuba var. spinosa ameliorates cognitive impairment induced by cholinergic blockade in mice. Biomol Ther 2013; 21(4): 299.
14. Pahuja M, Mehla J, Reeta K, Joshi S, Gupta YK. Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. Epilepsy Behav 2011; 21(4): 356-63.
15. Gao QH, Wu PT, Liu JR, Wu CS, Parry JW, Wang M. Physico-chemical properties and antioxidant capacity of different jujube (Ziziphus jujuba Mill.) cultivars grown in loess plateau of China. Scientia Horticulturae 2011; 130(1): 67-72.
16. Chen J, Maiwulanjiang M, Lam KY, Zhang WL, Zhan JY, Lam CT, et al. A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase A. J Agricultural Food Chemistry 2014; 62(8): 1890-7.
17. Mahboubi M, Taghizadeh M, Talaei SA, Firozeh SMT, Rashidi AA, Tamtaji OR. Combined administration of Melissa officinalis and Boswellia serrata extracts in an animal model of memory. Iran J Psychiatry Behav Sci 2016; 10(3).
18. Chen Y, Zhang DQ, Liao Z, Wang B, Gong S, Wang C, et al. Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease. Mol Neurodegener 2015; 10(1): 1-14.
19. Betarbet R, Sherer TB, Greenamyre JT. Animal models of Parkinson's disease. Bioessays 2002; 24(4): 308-18.
20. Rabiei Z, Rafieian-Kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neurochemical Res 2014; 39(2): 353-60.
21. Yoo K-, Li H, Hwang IK, Choi JH, Lee CH, Kwon DY, et al. Zizyphus attenuates ischemic damage in the gerbil hippocampus via its antioxidant effect. J Med Food 2010; 13(3): 557-63.
22. Zhao X, Yi L. Effect of Ziziphus jujube leaf extract on the central nervous system. Lishizhen Med Mater Med Res 2009; 20: 463-4.
23. Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol 2009; 122(3): 555-60.
24. Alipour Nosrani E, Tamtaji OR, Alibolandi Z, Sarkar P, Ghazanfari M, Azami Tameh A, et al. Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study. J Immunoassay Immunochem 2021; 42(2): 106-20.
25. Beckstead RM, Domesick VB, Nauta WJ. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res 1979; 175(2): 191-217.
26. Zare-Zardini H, Tolueinia B, Hashemi A, Ebrahimi L, Fesahat F. Antioxidant and cholinesterase inhibitory activity of a new peptide from Ziziphus jujuba fruits. Am J Alzheimers Dis Other Demen 2013; 28(7): 702-9.
27. Kaeidi A, Taati M, Hajializadeh Z, Jahandari F, Rashidipour M. Aqueous extract of Zizyphus jujuba fruit attenuates glucose induced neurotoxicity in an in vitro model of diabetic neuropathy. Iran J Basic Med Sci 2015; 18(3): 301.
28. Sun YF, Liang ZS, Shan CJ, Viernstein H, Unger F. Comprehensive evaluation of natural antioxidants and antioxidant potentials in Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex HF Chou fruits based on geographical origin by TOPSIS method. Food Chem 2011; 124(4): 1612-9.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alipour-Nosrani E, Ghazanfari M, Eslahi M, Hajijafari M, Taghizadeh M. The effect of Zizyphus jujube aqueous extract on learning, memory, locomotor activity and brain malondialdehyde level in rats with Parkinson’s disease. Feyz Med Sci J 2022; 26 (6) :629-636
URL: http://feyz.kaums.ac.ir/article-1-4693-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 26, Issue 6 (Bimonthly 2022) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4660