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:: Volume 26, Issue 3 (Bimonthly 2022) ::
Feyz 2022, 26(3): 264-272 Back to browse issues page
Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats
Mojdeh Nadaf-Fahmideh , Shahram Gholamrezaei * , Ramin Shabani
Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran. , gholamrezaei@iaurasht.ac.ir
Abstract:   (160 Views)
Background: Myocardial infarction is an acute condition of myocardial necrosis. So, this study aimed the effect of high intensity interval training with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression rats.
Materials and Methods: 32 male rats were randomly divided into 4 groups of HIIT, supplement, control and HIIT with supplement training in the two groups of high intensity and HIIT with supplement included performing 8 weeks of 4-minute activity with an intensity of 85-90% VO2max. Curcumin was also used at 100 mg / kg. Mitochondrial PGC-1α and ERR-α gene expression was obtained by real-time PCR. Data were analyzed by ANOVA and Shapiro-Wilk at P≤0.05.
Results: One-way analysis of variance test showed a significant difference in the expression of mitochondrial cardiomyocyte PGC-1α and ERR-α genes in male myocardial infarction mice in the study groups (P=0.001). The results of Tukey test showed a significant increase in PGC-1α and ERR-α gene expression in the HIIT and HIIT groups with supplementation compared to the control and supplement groups (P=0.001). There was no significant difference between the control and complement groups.
Conclusion: The results of this study showed that interval training alone and in interaction with curcumin increases the expression of ERRα and PGC-1α in the heart tissue of male stroke model mice. It seems that interval training and consumption of curcumin can be considered a good way to increase mitochondrial biogenesis and improve heart function.
Keywords: High intensity interval training, Curcumin, PGC-1α, ERR-α
Full-Text [PDF 381 kb]   (65 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/04/27 | Accepted: 2022/07/4 | Published: 2022/07/30
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Nadaf-Fahmideh M, Gholamrezaei S, Shabani R. Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats. Feyz. 2022; 26 (3) :264-272
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Volume 26, Issue 3 (Bimonthly 2022) Back to browse issues page
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