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:: Volume 25, Issue 6 (Bimonthly 2021) ::
Feyz 2021, 25(6): 1342-1353 Back to browse issues page
Long-term prognosis of rheumatoid arthritis disease: A multi centric retrospective cohort study
Kamal Esalatmanesh , Hamidreza Gilasi , Asma Ziarati , Mohammadjavad Azadchehr , Roozbeh Esalatmanesh
Medical Student, Kashan University of Medical Sciences, Kashan, I.R. Iran. , esalatr@gmail.com
Abstract:   (1428 Views)
Background: Rheumatoid arthritis is the most common chronic systemic inflammatory and autoimmune disease. Considering that one of the important goals of treatment of this disease is to achieve remission, this study was designed to identify the factors associated with the prognosis of this disease to select a treatment appropriate to its severity.
Materials and Methods: In this study, the records of 433 patients with rheumatoid arthritis were examined by several rheumatologists and their assistants in Tabriz and Kashan centers and the factors affecting the prognosis of patients using logistic regression test was determined.
Results: Results showed that the variables of disease duration, DAS28 at the first visit, treatment regimen and TNF inhibitors have a significant effect on patients' prognosis (P <0.05) so that with an increase of one unit (year) duration of the disease, the chance of a poor prognosis in patients increases 1.117 times; The chance of a poor prognosis among patients in whom the disease activity was severe at the beginning of the referral is 2.369 times higher than in patients in whom the disease activity was moderate; Also, the chance of a poor prognosis among patients on a mono-therapy regimen is 9.346 times higher than in patients on a double-therapy regimen.
Conclusion: Increasing duration of the disease, severe disease activity at the beginning of the visit, lack of commitment to treatment and use of a mono-therapy regimen at the beginning of treatment increase the chance of poor prognosis in patients.
Keywords: Rheumatoid arthritis, Long-term prognosis, Remission
Full-Text [PDF 396 kb]   (1043 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2021/09/17 | Revised: 2023/11/1 | Accepted: 2021/11/13 | Published: 2022/02/1
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Esalatmanesh K, Gilasi H, Ziarati A, Azadchehr M, Esalatmanesh R. Long-term prognosis of rheumatoid arthritis disease: A multi centric retrospective cohort study. Feyz 2021; 25 (6) :1342-1353
URL: http://feyz.kaums.ac.ir/article-1-4471-en.html


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Volume 25, Issue 6 (Bimonthly 2021) Back to browse issues page
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