History and Objectives: Upper gasterointestinal (UGI) bleeding is a common cause of admission in the medical and surgical wards. Due to its importance and different causes of bleeding, the present study was carried out to investigate the causes of UGI bleeding and their relationship to the laboratory and clinical data.

Materials and Methods: A descriptive study on existing data on 114 patients who were admitted to the ward with UGI bleeding was carried out.

Results: The most common cause of UGI bleeding was peptic ulcer (46.5%) and other less frequent causes of bleeding were gastritis (33.3%), duodenitis (6.1%), gastroduodenitis (3.5%), esophageal varices (3.5%), esophagitis (1.8%) and esophageal ulcer (0.9%). Five cases had normal endoscopic finding (4.4%) from which 4 cases were due to NASAIDs application. 45.6% of patients used NSAID60 for different causes.

Conclusion: UGI bleeding is one of the common causes of referral to emergency departments. NSAID plays an important role in UGI bleeding. Therefore correct usage of NSAID is recommended. The most common cause of UGI bleeding is peptic ulcer disease. Further researches are needed to evaluate the effect of H.pylori treatment to prevent UGI bleeding.